置管溶栓联合肝素间歇性脉冲抗凝在急性下肢深静脉血栓患者中的应用效果

doi:10.3969/j.issn.1671-7171.2025.08.024

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Abstract 【Objective】To investigate the application effect of catheter-directed thrombolysis combined with intermittent pulsed heparin anticoagulation in acute lower extremity deep vein thrombosis (DVT). 【Methods】 A total of 102 patients with acute lower extremity DVT admitted to our hospital from May 2023 to May 2024 were selected and divided into the control group (receiving conventional thrombolytic therapy) and the observation group (receiving continuous 24-hour pump infusion of urokinase combined with intermittent pulsed heparin irrigation) using a random number table method, with 51 patients in each group. The clinical efficacy, swelling relief degree, venous patency, pain level, laboratory indicators [activated partial thromboplastin time (APTT), fibrinogen (Fib), D-dimer (D-D) detected by chemiluminescence method], incidence of adverse reactions, and recurrence were compared between the two groups. 【Results】The clinical effective rate in the observation group was 96.08% (49/51), which was higher than that in the control group (80.39%, 41/51), with a statistically significant difference (χ²=6.044, P<0.05). After treatment, the swelling relief degree in both groups was higher than that before treatment, and it was higher in the observation group than in the control group (P<0.05). The venous patency and VAS scores in both groups were lower than those before treatment, and they were lower in the observation group than in the control group (P<0.05). After treatment, the APTT in both groups was longer than that before treatment, and it was longer in the observation group than in the control group (P<0.05). The levels of Fib, D-D, and CRP were lower than those before treatment, and they were lower in the observation group than in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The postoperative thrombus clearance rate and 1-year vascular patency rate in the observation group were higher than those in the control group, while the 1-year recurrence rate was lower than that in the control group, with statistically significant differences (P<0.05). 【Conclusion】Catheter-directed thrombolysis combined with intermittent pulsed heparin anticoagulation demonstrates good application effects in acute lower extremity DVT. It helps improve venous patency, alleviate lower extremity swelling, reduce thrombosis recurrence rate, and shows favorable clinical outcomes.

Key words： Thrombolytic Therapy Lower Extremity Venous Thrombosis Acute Disease Treatment Outcome

Received: 21 April 2025

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R364.15

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	LIU Zhijie

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LIU Zhijie. Application Effect of Catheter-Directed Thrombolysis Combined with Intermittent Pulsed Anticoagulation in Patients with Acute Lower Extremity Deep Vein Thrombosis[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(8): 1378-1381.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.08.024 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I8/1378

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