D-二聚体与NLR联合检测对社区获得性细菌性肝脓肿患者预后的预测价值

doi:10.3969/j.issn.1671-7171.2025.08.021

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1238 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the prognostic value of combined detection of plasma D-dimer (D-D) and peripheral blood neutrophil-to-lymphocyte ratio (NLR) in patients with community-acquired bacterial liver abscess (CABHA).【Methods】 Plasma D-D and peripheral blood NLR levels were measured in 94 CABHA patients. Based on 6-month follow-up outcomes, patients were divided into a good prognosis group and a poor prognosis group. Factors influencing prognosis were analyzed, and the predictive value of combined D-D and NLR detection was evaluated.【Results】Among the 94 patients, 75 (79.79%) had good prognosis and 19 (20.21%) had poor prognosis. Logistic regression analysis showed that a history of diabetes, multiple abscesses, maximum abscess diameter >5 cm, and elevated serum D-D and NLR levels were all risk factors for the poor prognosis in CABHA patients (P<0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) for predicting prognosis using D-D alone, NLR alone, and combined both D-D and NLR detection was 0.734, 0.726, and 0.797, respectively, with combined detection showing significantly better predictive performance than single indicator(Z=7.104, P<0.05).【Conclusion】 Plasma D-D and peripheral blood NLR levels can be used to evaluate the prognosis of patients with CABHA.

Key words： Liver Abscess Bacterial Infections Fibrin Fibrinogen Degradation Products Odds Ratio Lymphocytes Neutrophils Prognosis

Received: 29 May 2025

PACS:

R575.4

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	DONG Jin
	SHAN Fuqiang
	LI Huimin

Cite this article:

DONG Jin,SHAN Fuqiang,LI Huimin. Predictive Value of Combined Detection of D-Dimer and NLR for Prognosis of Community-Acquired Bacterial Liver Abscess[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(8): 1367-1369.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.08.021 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I8/1367

[1] 赵英,杜娜,李晓华,等. 细菌性肝脓肿合并肝硬化和单纯细菌性肝脓肿诊疗比较及相关影响因素分析[J].中西医结合肝病杂志,2019,29(4):325-328.
[2] 蔡清源,吴晓敏,骆剑煌,等. 细菌性肝脓肿超声引导下置管引流疗效的影响因素分析[J].中国超声医学杂志,2021,37(2):167-169.
[3] 侯秋晨,戴明佳,韩方正. 细菌性肝脓肿合并2型糖尿病的临床特征及疗效预测因素分析[J].徐州医科大学学报,2021,41(3):194-199.
[4] 郭晓会. 血浆D-二聚体在乙肝后肝硬化患者中的表达及与预后的关系[J].现代中西医结合杂志,2019,28(30):3346-3348.
[5] 杨娜,何华,赵天业,等. 红细胞分布宽度/血小板比值、血小板/淋巴细胞比值、中性粒细胞/淋巴细胞比值对慢性丙型肝炎肝硬化代偿期的预测价值[J].临床肝胆病杂志,2021,37(6):1319-1325.
[6] 中华医学会.临床诊疗指南:外科学分册[M]. 北京:人民卫生出版社,2008:43-47.
[7] 刘瑶,刘槿晴,傅蕾,等. 细菌性肝脓肿患者528例的临床特征分析[J].中华传染病杂志,2021,39(9):536-541.
[8] 柯山,王劭宏,孔新亮,等. 射频消融治疗难治性细菌性肝脓肿[J].中华肝胆外科杂志,2018,24(8):505-509.
[9] 刘瑞红,廉恒丽. P-选择素和D二聚体对肝硬化门静脉血栓形成的早期预测价值[J].血栓与止血学,2021,27(6):974-976.
[10] 乐华文,王依屹. 凝血、纤溶和抗凝指标在慢性乙型肝炎病情进展中的变化规律[J].检验医学与临床,2020,17(6):755-757.
[11] 施海东,马建明. PLR和NLR与慢性乙型肝炎病毒感染的相关性研究[J].现代消化及介入诊疗,2020,25(9):1156-1162.
[12] 苗静,郭丽颖,王丽,等. MELD-Na、CLIF-C OFs、COSSH-ACLFs、NLR评分体系在乙型肝炎病毒相关慢加急性肝衰竭患者中的应用价值研究[J].中华危重病急救医学,2020,32(12):1496-1501.
[13] 潘教治,王仙敏,黄友全,等. 糖尿病合并细菌性肝脓肿424例临床分析[J].中华临床感染病杂志,2021,14(3):199-202.
[14] 董叶子,安莹波. 细菌性肝脓肿的临床特征及其危险因素分析[J].肝脏,2020,25(3):325-327.