超声引导下经皮穿刺置管引流术治疗重症急性胰腺炎患者继发感染的危险因素

doi:10.3969/j.issn.1671-7171.2025.03.028

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Abstract 【Objective】To investigate the risk factors of secondary infection in patients with severe acute pancreatitis treated by ultrasound-guided percutaneous catheter drainage (PCD). 【Methods】The clinical data of 70 patients with severe acute pancreatitis treated with ultrasound-guided PCD from January 2021 to January 2024 were retrospectively analyzed, and the patients were divided into infected group (n=28) and uninfected group (n=42) according to whether they had secondary infection. Clinical data of all patients were collected, and clinical data and related laboratory indicators [albumin (ALB), white blood cell (WBC) count, hypersensitive C-reactive protein (hs-CRP), procalcitonin (PCT), platelet count (PLT), blood urea nitrogen (BUN)] of the two groups were compared. Multivariate Logistic regression was used to analyze the risk factors of secondary infection in patients with severe acute pancreatitis. 【Results】 The age of the infected group was ≥60 years old, the APACHE Ⅱ score at admission was > 11 points, the mechanical ventilation time was ≥6 days, the proportion of hypoxemia and multiple organ failure was higher than that of the uninfected group, and the WBC, PCT and hs-CRP were higher than that of the uninfected group, with statistical significance (P<0.05). Multivariate Logistic regression analysis showed that increased WBC count, increased hs-CRP, increased PCT, age ≥60 years, APACHE Ⅱ score > 11 points upon admission, mechanical ventilation duration ≥6 days, hypoxemia and multiple organ failure were risk factors for secondary infection in patients with severe acute pancreatitis (P<0.05).【Conclusion】Secondary infection after treatment of severe acute pancreatitis with ultrasound-guided PCD is related to age, APACHE Ⅱ score at admission, mechanical ventilation time, hypoxemia, multiple organ failure and other factors. WBC count, hs-CRP and PCT can be used as predictors of secondary infection of severe acute pancreatitis.

Key words： Pancreatitis, Acute Necrotizing Punctures Catheters, Indwelling Drainage

Received: 14 October 2024

PACS:

R576.1

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	SUN Xianglei
	LI Ya
	WANG Yan

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SUN Xianglei,LI Ya,WANG Yan. Risk Factors of Secondary Infection in Patients with Severe Acute Pancreatitis Treated by Ultrasound-Guided Percutaneous Catheter Drainage[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(3): 463-466.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.03.028 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I3/463

[1] MOGGIA E,KOTI R,BELGAUMKAR A P, et al. Pharmacological interventions for acute pancreatitis[J].Cochrane Database Syst Rev,2017,4(4):CD011384.
[2] GANAIE K H, CHOH N A, PARRY A H, et al. The effectiveness of image-guided percutaneous catheter drainage in the management of acute pancreatitis-associated pancreatic collections[J].Pol J Radiol,2021,86:359-365.
[3] 赵海鹏,李俊莹,张晓红,等. 肝素结合蛋白、降钙素原、中性粒细胞载脂蛋白联合检测对重症急性胰腺炎患者继发感染的评估作用[J].中国实验诊断学,2020,24(11):1816-1818.
[4] TIAN H, CHEN L, WU X D, et al. Infectious complications in severe acute pancreatitis: pathogens, drug resistance, and status of nosocomial infection in a university-affiliated teaching hospital[J].Dig Dis Sci,2020,65(7):2079-2088.
[5] 李涛. 实验室指标对急性胰腺炎发生器官衰竭的预测价值[J].中国中西医结合消化杂志,2021,29(3):218-221.
[6] 中国中西医结合学会普通外科专业委员会. 重症急性胰腺炎中西医结合诊治指南(2014年,天津)[J].临床肝胆病杂志,2015,31(3):327-331.
[7] SAEED S A. Acute pancreatitis in children: Updates in epidemiology, diagnosis and management[J].Curr Probl Pediatr Adolesc Health Care,2020,50(8):100839.
[8] 周珊珊,陈婷,张婷,等. 重症急性胰腺炎继发感染患者外周血单核细胞表面HLA-DR/CD14⁺的表达变化[J].中华医院感染学杂志,2020,30(17):2661-2665.
[9] 中华医学会外科学分会胰腺外科学组. 中国急性胰腺炎诊治指南(2021)[J].中华外科杂志,2021,59(7):578-587.
[10] 彭越岭,高青. 重症急性胰腺炎继发真菌感染120例患者的临床特点和危险因素分析[J].中华消化杂志,2021,41(7):466-470.
[11] 谢红,张雅卫,吴丹阳. 重症急性胰腺炎继发胰腺感染的临床特点和影响因素分析[J].中华医院感染学杂志,2019,29(5):730-733.
[12] 吴思远,胡玉霆,巢佳灯,等. 156例重症急性胰腺炎患者继发感染的病原菌检出情况及感染高危因素分析[J].中国病原生物学杂志,2020,15(11):1336-1339.
[13] 韩晓环,李梅霞,吴娜娜.低分子肝素联合前列地尔治疗高脂血症性SAP患者的临床疗效[J].医学临床研究,2024,41(3):389-392.
[14] EBIK B, KACMAZ H, TUNCEL E T, et al. What does the procalcitonin level tell us in patients with acute pancreatitis?[J].J Coll Physicians Surg Pak,2022,32(10):1272.
[15] 则学英,安春霞,刘磊,等. 重症急性胰腺炎合并腹腔感染患者血清Ghrelin、AMS、hs-CRP的表达水平及预后价值分析[J].中国现代医学杂志,2021,31(24):42-49.
[16] 韦艳萍,黄勤英,廖帅,等. 重症急性胰腺炎继发感染危险因素及外周血炎症指标预测价值[J].中华医院感染学杂志,2021,31(15):2332-2336.