京都胃炎分类评分结合醋酸-靛胭脂染色放大内镜对早期胃癌的诊断价值

doi:10.3969/j.issn.1671-7171.2025.02.025

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Abstract 【Objective】To explore the diagnostic value of the Kyoto Classification of Gastritis (KCS) score combined with acetic acid-indigo carmine staining magnification endoscopy in early gastric cancer.【Methods】Ninety-eight early gastric cancer patients who underwent endoscopic submucosal dissection (ESD) were included in the observation group, and 57 non-cancer patients who were scheduled for endoscopy due to upper abdominal discomfort (such as bloating and pain) were included in the control group. According to the KCS, patients were divided into the low-score group (n=79, <4 points) and the high-score group (n=76, ≥4 points). Clinical data and KCS scores of the observation group and the control group were compared, and the proportion of gastric cancer cases in the high-score group and the low-score score groups were compared as well. Factors influencing early gastric cancer occurrence were screened, and receiver operating characteristic (ROC) curves were generated to assess the diagnostic value using the area under the curve (AUC).【Results】The KCS score in the observation group was significantly higher than that in the control group (P<0.05). The proportion of gastric cancer cases in the high-score group was significantly higher than that in the low-score group (P<0.05). Acetic acid-indigo carmine staining magnification endoscopy detected 81 cases of early gastric cancer and 17 non-cancer cases (6 cases with atypical hyperplasia and 11 cases with intestinal metaplasia). The pepsinogen (PG)Ⅰ/PGⅡ ratio in the observation group was lower than that in the control group (P<0.05). Helicobacter pylori (HP) urease antibody, carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199), carcinoembryonic antigen (CEA), PGⅠ/Ⅱ, and KCS were identified as factors related to early gastric cancer occurrence (P<0.05). The AUC values for KCS, acetic acid-indigo carmine staining magnification endoscopy, and their combined use in diagnosing early gastric cancer were 0.820, 0.852, and 0.882, respectively, with the combined approach showing a higher AUC value (P<0.05).【Conclusion】KCS and acetic acid-indigo carmine staining magnification endoscopy are effective in diagnosing early gastric cancer, while the combination of the two methods provides even higher diagnostic value.

Key words： Stomach Neoplasms Endoscopy, Gastrointestinal Diagnosis, Differential

Received: 14 September 2024

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R735.2

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	MEN Zhongjun
	LIU Yun
	JIA Huiwen

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MEN Zhongjun,LIU Yun,JIA Huiwen. Diagnostic Value of Kyoto Classification of Gastritis Score Combined with Acetic Acid-Indigo Carmine Staining Magnification Endoscopy in Early Gastric Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(2): 261-264.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.02.025 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I2/261

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