原发性高血压患者的血压昼夜节律、血压变异性与外周动脉粥样硬化的相关性

doi:10.3969/j.issn.1671-7171.2025.02.015

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Abstract 【Objective】To investigate the relationship between blood pressure circadian rhythm, blood pressure variability and ankle-brachial index (ABI) in patients with essential hypertension.【Methods】A total of 176 patients with essential hypertension admitted to our hospital from September 2021 to December 2023 were selected and divided into sclerotic group (n=90) and non-sclerotic group (n=86) according to the detection results of anklebrachial index (ABI). Patients were divided into arytenoid group (n=48), non-arytenoid group (n=94) and reverse arytenoid group (n=34) according to circadian rhythm of blood pressure. The non-sclerotic group and the sclerotic group were compared in terms of the ambulatory blood pressure index [24 h systolic blood pressure (24hSBP), daytime systolic blood pressure (dSBP), night systolic blood pressure (nSBP), and 24 h diastolic blood pressure (24hDBP), daytime diastolic blood pressure (dDBP), night diastolic blood pressure (nDBP)] and the indicators of blood pressure variability [24 h standard deviation of systolic blood pressure (24hSSD), 24 h standard deviation of diastolic blood pressure (24hDSD), standard deviation of diastolic blood pressure (dSSD), standard deviation of diastolic blood pressure (dDSD), standard deviation of nocturnal systolic blood pressure (nSSD), standard deviation of nocturnal diastolic blood pressure (nDSD)]. The decreasing rate of systolic blood pressure (ΔSBP%) and the decreasing rate of diastolic blood pressure at night (ΔDBP%) were calculated. Pearson was used to analyze the correlation between circadian rhythm of blood pressure and peripheral atherosclerosis, and multiple Logistic regression was used to analyze the influencing factors of peripheral atherosclerosis.【Results】24hSBP, dSBP, nSBP, 24hSSD, 24hDSD, dSSD, nSSD, nDSD in hardening group were higher than those in non-hardening group, and ΔSBP% was lower than that in non-hardening group, the difference was statistically significant (P<0.05). ABI of non-arytenoid group and reverse arytenoid group was significantly lower than that of arytenoid group, and the difference was statistically significant (P<0.05). Pearson correlation analysis showed that ABI was negatively correlated with ΔSBP%, the difference was statistically significant (r=-0.406,P=0.044). Logistic regression analysis showed that the increase of 24hSSD and nSSD was a risk factor for peripheral atherosclerosis (P<0.05).【Conclusion】Abnormal circadian rhythm and variability of blood pressure are important factors leading to atherosclerosis, and correct analysis of blood pressure variation is an effective measure to prevent and intervene atherosclerosis.

Key words： Essential Hypertension Blood Pressure Circadian Rhythm Ankle Brachial Index

Received: 02 December 2024

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R544.1

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	HUANG Yingrui
	ZHU Xuemei
	NIE Shuxuan
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HUANG Yingrui,ZHU Xuemei,NIE Shuxuan, et al. Relationship between Circadian Rhythm, Blood Pressure Variability and Peripheral Atherosclerosis in Patients with Essential Hypertension[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(2): 228-231.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.02.015 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I2/228

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