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| Diagnostic Value of Serum sCD14 Combined with sCD30 in Elderly Patients with Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Fungal Infection |
| YANG Jianhua |
| Department of Internal Medicine, the Fifth People's Hospital of Taizhou, Taizhou Jiangsu 225300 |
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Abstract 【Objective】To investigate the diagnostic value of serum soluble 14 (sCD14) combined with sCD30 in elderly patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary fungal infection.【Methods】A total of 80 elderly patients with COPD admitted to our hospital from April 2021 to June 2023 were selected and divided into group A (n=23, combined with pulmonary fungal infection) and group B (n=57, not combined with pulmonary fungal infection), using fungal culture as the gold standard. Serum sCD14 and sCD30 levels were detected by ELISA on the second day of admission in the two groups, and the influencing factors of senile COPD combined with pulmonary fungal infection and the efficacy of serum sCD14 and sCD30 in diagnosis of senile COPD combined with pulmonary fungal infection were analyzed.【Results】The Acute physiology and Chronic Health status Scoring System Ⅱ (APACHE Ⅱ) scores and the levels of sCD14, sCD30 and C-reactive protein (CRP) in group A were higher than those in group B (P<0.05). Binary Logistic regression analysis showed that APACHE Ⅱ score and high levels of sCD14, sCD30 and CRP were risk factors for pulmonary fungal infection in elderly patients with COPD (P<0.05). APACHE Ⅱ score combined with serum sCD14, sCD30 and CRP were more effective than single index in predicting pulmonary fungal infection in elderly patients with COPD.【Conclusion】APACHEⅡ score combined with serum sCD14, sCD30 and CRP has a high predictive value for pulmonary fungal infection in elderly patients with COPD.
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Received: 09 May 2024
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2025, Vol. 42 
