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| Effect of Antiandrogen Withdrawal Therapy on Cognitive Function in Castration-resistant Prostate Cancer Patients |
| HAN Jingjing |
| Anyang Cancer Hospital, Anyang Henan 455000 |
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Abstract 【Objective】To investigate the effect of antiandrogen withdrawal therapy on cognitive function in castration-resistant prostate cancer (CRPC).【Methods】The clinical data of 100 patients with castration-resistant prostate cancer admitted to our hospital from February 2018 to March 2023 were retrospectively analyzed, and they were divided into the observation group and the control group according to whether the patients were treated with antiandrogynous drug withdrawal, with 50 cases in each group. The score of Montreal Cognitive Assessment Scale (MoCA), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) and neuropsychological cognitive function test [Auditory Word Learning Test (AVLT), Number Range Test (DS), Connected Task Test (TMT), Verbal Fluency Test (VF), Classic Stroop paradigm test] were compared between the two groups. Pearson correlation was used to analyze the correlation between the outcome of antiandrogenic drug withdrawal and the degree of cognitive impairment.【Results】MoCA scores in the observation group were significantly lower than those in the control group, and HAMA and HAMD scores were higher than those in the control group, with statistical significance (P<0.05). The recognition memory score and anteroposteric number score in the observation group were lower than those in the control group, and the time of classic Stroop paradigm C test, TMT A test and TMT B test were longer than those in the control group, with statistical significance (P<0.05). Pearson correlation analysis showed that the results of antiandrogant withdrawal treatment were positively correlated with cognitive function, anxiety state and recognition memory ability of patients (P<0.05), and negatively correlated with TMT A test time and TMT B test time (P<0.05).【Conclusion】CRPC patients treated with antiandrogen withdrawal showed decreased cognitive function, recognition memory ability, anterograde digital breadth, executive function, information processing ability, and increased anxiety and depression. For CRPC patients treated with antiandrogen withdrawal, intervention measures should be paid attention to before initiation and during treatment, which can improve the cognitive function of patients.
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Received: 18 July 2023
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(2): 364-366. |
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2025, Vol. 42 
