丙戊酸口服液联合左乙拉西坦口服液治疗儿童癫痫的临床效果及对患儿认知功能的影响

doi:10.3969/j.issn.1671-7171.2025.01.032

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Abstract 【Objective】To investigate the clinical effect of valproic acid oral liquid combined with levetiracetam oral liquid in the treatment of children with epilepsy and its influence on cognitive function. 【Methods】A total of 36 children with epilepsy admitted to our hospital from February 2021 to February 2023 were divided into combination group and routine group according to treatment methods, with 18 cases in each group. The conventional group was given valproic acid oral liquid, and the combined group was combined with levetiracetam oral liquid on the basis of the conventional group. Both groups were treated for 6 months. The two groups were compared in terms of the efficacy, clinical symptom improvement (seizure frequency, seizure duration) and cognitive function [verbal intelligence quotient (VIQ), operational intelligence quotient (PIQ), full scale intelligence quotient (FIQ)], neurotransmitter [S-100β protein, high mobility group protein-1 (HMGB-1), neuropeptide Y (NPY), galanin (GAL)] and incidence of adverse reactions. 【Results】The total effective rate of the combined group was higher than that of the conventional group, the difference was statistically significant (P<0.05). After treatment, the seizure frequency of the two groups was lower than before treatment, and the seizure time was shorter than before treatment, and the seizure frequency of the combined group was lower than that of the conventional group, and the seizure time was shorter than that of the conventional group, with statistical significance (P<0.05). After treatment, VIQ, PIQ and FIQ scores in 2 groups were higher than before treatment, and the combined group was higher than the conventional group (P<0.05). After treatment, the levels of serum S-100β protein and HMGB-1 were lower than before treatment, and the levels of serum NPY and GAL were higher than before treatment, and the difference was statistically significant between the combined group and the conventional group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】Valproic acid oral liquid combined with levetiracetam oral liquid is effective in the treatment of children with epilepsy, which can effectively reduce the frequency and duration of seizures and reduce the damage to cognitive function of children.

Key words： Epilepsy Valproic Acid Levetiracetam Cognition Treatment Outcome Child

Received: 16 August 2023

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R742.1

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	Articles by authors
	CUI Xiaolin
	ZONG Jiwen
	WANG Chunxiao

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CUI Xiaolin,ZONG Jiwen,WANG Chunxiao. Clinical Effect of Valproic Acid Oral Liquid Combined with Levetiracetam Oral Liquid in the Treatment of Children with Epilepsy and its Influence on Cognitive Function[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(1): 112-115.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.01.032 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I1/112

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