支气管肺炎患儿抗生素治疗前后肠道菌群的变化及其临床意义

doi:10.3969/j.issn.1671-7171.2024.10.016

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Abstract 【Objective】To investigate the changes and clinical significance of intestinal flora in children with bronchial pneumonia before and after antibiotic treatment. 【Methods】A total of 112 children with bronchopneumonia treated in our hospital from October 2020 to October 2022 were selected as the observation group and given macrolide antibiotics for 14 days. In addition, 60 healthy children who underwent physical examination in our hospital during the same period were selected as the control group. The intestinal flora of children with bronchopneumonia of different severity were compared between the two groups and the observation group. The imbalance of intestinal flora in children of different age groups after treatment was analyzed. 【Results】Shigella, Salmonella and pathogenic Escherichia coli in observation group were significantly higher than those in control group (P<0.05). Shigella, salmonella and pathogenic Escherichia coli increased successively in mild, moderate and severe children in the observation group, and the differences were statistically significant (P<0.05). After treatment with antibiotics, the contents of Shigella, Salmonella and pathogenic Escherichia coli in children with bronchopneumonia were higher than those before treatment (P<0.05). The proportion of children < 3 years old with intestinal flora disorder was higher than that of children ≥3 years old (χ²=11.479, P<0.05). 【Conclusion】The intestinal flora of children with bronchopneumonia is dysregulated, and antibiotic treatment can further affect the intestinal flora. Children < 3 years old are prone to intestinal flora dysregulation.

Key words： Bronchopneumonia/TU Anti-Bacterial Agents Gastrointestinal Microbiome

Received: 18 March 2024

PACS:

R725.631.2

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	Articles by authors
	ZHONG Yujie
	ZHANG Yanan
	HU Shuaijuan

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ZHONG Yujie,ZHANG Yanan,HU Shuaijuan. Changes of Intestinal Flora in Children with Bronchopneumonia before and after Antibiotic Treatment and its Clinical Significance[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(10): 1512-1514.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.10.016 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I10/1512

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