内镜下乳头括约肌小切开联合球囊扩张治疗胆管结石患者的疗效及对血清CCK-A、SREBP-2水平的影响

doi:10.3969/j.issn.1671-7171.2024.10.015

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Abstract 【Objective】To explore the efficacy of endoscopic papillary mini-incision combined with balloon dilation in the treatment of bile duct stones and its impact on serum levels of cholecystokinin type A receptor (CCK-A) and cholesterol regulatory element binding protein 2 (SREBP-2). 【Methods】A total of 196 patients with bile duct stones admitted to our hospital from January 2019 to December 2023 were selected and divided into the observation group and the control group based on a random number table method, with 98 cases in each group. The patients in the control group underwent endoscopic sphincterotomy for gallstone surgery, while the patients in the observation group underwent endoscopic papillary mini-incision combined with balloon dilation. The operation time, blood loss, hospitalization, time to get-out-of bed, and gastrointestinal function recovery time were compared between the two groups. The stone removal rate, stone recurrence rate, and postoperative complication incidence were compared between the two groups as well. 【Results】The observation group had significantly lower operation time, blood loss,hospitalization time, time to get-out-of bed, and gastrointestinal function recovery time compared to the control group (P<0.05). The success rate for one time of stone removal in the observation group was higher than that in the control group (P<0.05), while the mechanical lithotripsy rate and stone recurrence rate in the observation group were lower than those in the control group (P<0.05). There was no statistically significant difference in the residual stone rate between the observation group and the control group (P>0.05). After surgery, the CCK-A of the two groups of patients was higher than that before surgery, and the SREBP-2 was lower than that before surgery. The postoperative CCK-A in the observation group was higher than that in the control group, while the postoperative SREBP-2 level was lower than that in the control group, with a statistically significant difference (P<0.05). The total incidence of postoperative complications in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). 【Conclusion】The combination of endoscopic papillary mini-incision and balloon dilation for the treatment of bile duct stones has advantages such as short surgical time, quick postoperative recovery, good postoperative gallbladder function recovery, and fewer complications.

Key words： Gallstones/SU Sphincterotomy, Endoscopic Balloon Dilatation Receptor, Cholecystokinin A/BL Sterol Regulatory Element Binding Protein 2/BL

Received: 10 January 2024

PACS:

R657.42

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	TANG Wenjun
	QIN Xianju

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TANG Wenjun,QIN Xianju. The Efficacy of Endoscopic Papillary Mini-incision Combined with Balloon Dilation in the Treatment of Patients with Bile Duct Stones and Impact on Serum Levels of CCK-A and SREBP-2[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(10): 1508-1511.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.10.015 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I10/1508

[1] SUN H, WARREN J, YIP J, et al. Factors influencing gallstone formation: a review of the literature[J].Biomolecules,2022,12(4):550.
[2] 李静,苗龙,周文策.消化道微生态与胆结石疾病关系的研究进展[J].中国普通外科杂志,2020,29(8):1000-1005.
[3] SCHEPERS N J, HALLENSLEBEN N D L, BESSELINK M G, et al. Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial[J].Lancet,2020,396(10245):167-176.
[4] 郑桂龙,丁海华,丁志清,等. 内镜下乳头小切开联合球囊扩张术治疗胆总管较大结石的临床效果[J].中国普外基础与临床杂志,2017,24(4):474-477.
[5] KÖKSAL A Ş,EMINLER A T,PARLAK E. Biliary endoscopic sphincterotomy: techniques and complications[J].World J Clin Cases,2018, 6(16): 1073-1086.
[6] TSAI T J, LIN C K, LAI K H,et al. Does preserved sphincter of Oddi function prevent common bile duct stones recurrence in patients after endoscopic papillary balloon dilation?[J].Chin Med Assoc,2018,81(4):311-315.
[7] 方宇韬,沈红璋,金杭斌,等.内镜下乳头球囊扩张术治疗胆总管结石并发十二指肠乳头出血的危险因素分析(含视频)[J].中华消化内镜杂志,2021,38(7):560-564.
[8] 龚敏,文萍,韩坚云,等.内镜下乳头小切开联合球囊扩张治疗胆总管结石合并十二指肠乳头旁憩室的价值[J].实用医学杂志,2018,34(8):1313-1315.
[9] 樊怡茹,孙淑珍,王红建.经内镜乳头括约肌小切开联合球囊扩张术治疗老年胆总管结石患者的疗效与安全性分析[J].中国现代医学杂志,2021,31(6):91-96.
[10] 彭书旺,陈露阳.腹腔镜下胆道切开取石术和ERCP球囊扩张取石术治疗细径胆管结石的疗效比较[J].中国现代手术学杂志,2019,23(5):321-324.
[11] 李秋菊.胆囊收缩素及其受体的研究进展[J].重庆医学,2021,50(20):3571-3575.
[12] 章波,黄磊,黄侠.内镜下乳头括约肌小切开术联合球囊扩张术治疗非扩张性肝外胆管结石患者疗效再研究[J].实用肝脏病杂志,2021,24(1):135-138.
[13] 高黎黎,张霞芬,张昊. 内镜下球囊扩张术和括约肌小切开术治疗非扩张性肝外胆管结石的临床分析[J].实用医学杂志,2021,37(14):1846-1851.
[14] 王庆华,韩玮,包洁,等.内镜下乳头括约肌小切开术联合球囊扩张术治疗胆总管结石的临床价值[J].中国内镜杂志,2020,26(2):32-36.