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| Comparison of Clinical Efficacy of Different Formulations of Leuprorelin in the Treatment of Central Precocious Puberty in Girls |
| ZHOU Yuanyuan, ZHAO Sha |
| Hunan Children's Hospital, Affiliated Children's Hospital, Xiangya School of Medicine, Central South University, Changsha Hunan 410007 |
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Abstract 【Objective】To compare the clinical efficacy of dosage form 3M and 1M of leuprorelin in the treatment of central precocious puberty (CPP) in girls. 【Methods】A total of 35 children with CPP admitted to the Department of Child Health Care of our hospital from July 2022 to August 2023 were retrospectively analyzed and divided into the observation group (n=17) and the control group (n=18) according to different treatment methods. Sex hormone levels [luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2)], uterine length, ovarian volume, height, weight, bone age/chronological age of the two groups before and after treatment were compared, and the occurrence of adverse reactions between the two groups were compared. 【Results】There were no significant differences in uterine length, left ovarian volume, right ovarian volume, bone age/actual age, height and body weight index (BMI) between the two groups before and after treatment (P>0.05). After 3 months of treatment, the peak levels of LH and FSH in 2 groups were lower than before treatment, and the difference was statistically significant (P<0.05). After 3 and 6 months of treatment, the levels of serum LH, FSH and E2 in the two groups were lower than before treatment, and the differences were statistically significant (P<0.05). After 3 months of treatment, serum LH and FSH levels in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】The two formulations of leuprorelin have similar clinical efficacy and safety in the treatment of CPP girls, and the long-acting formulations are economical and convenient.
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Received: 04 August 2024
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2024, Vol. 41 
