类风湿性关节炎患者外周血IGF-2及IGFBP-6与疾病活动度的相关性

doi:10.3969/j.issn.1671-7171.2024.03.030

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1142 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the correlation of disease activity with levels of insulin-like growth factor-2(IGF-2) and insulin-like growth factor binding protein-6(IGFBP-6) in the peripheral blood of patients with Rheumatoid Arthritis(RA). 【Methods】A total of 158 RA patients treated in our hospital were divided into high activity, moderate activity, and low activity groups based on the disease activity score of 28 joints. The levels of IGF-2 and IGFBP-6 in the peripheral blood of the three groups were compared. The relationship of different disease activities with the expression levels of IGF-2 and IGFBP-6 was evaluated; And the influencing factors of disease activity were analyzed as well.【Results】Among the 158 RA patients, 61(38.61%) were in the high activity group, 59(37.34%) in the moderate activity group, and 38(24.05%) in the low activity group. The IGF-2 level in the high activity group was higher than that in the moderate and low activity groups, while the IGFBP-6 level was lower than that in the moderate and low activity groups. The moderate activity group's IGF-2 level was higher than that of the low activity group, and the IGFBP-6 level was lower than that of the low activity group, with significant differences(P<0.05). There was a negative correlation of the disease activity with the expression level of IGF-2(P<0.001), and a positive correlation with the expression level of IGFBP-6(P<0.001). Multifactorial analysis showed that high white blood cell count, high expression level of IGF-2, and low expression level of IGFBP-6 were risk factors for high disease activity in RA patients(P<0.05).【Conclusion】In RA patients with high disease activity, the expression level of IGF-2 in peripheral blood is higher, which is negatively correlated with disease activity; And the expression level of IGFBP-6 in RA patients with high disease activity is lower, which is positively correlated with disease activity.

Key words： Arthritis, Rheumatoid Insulin-Like Growth Factor Ⅱ/BL

Received: 05 April 2023

PACS:

R593.22

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIN Hai
	ZHANG Bin
	WANG Yiyi

Cite this article:

LIN Hai,ZHANG Bin,WANG Yiyi. The Correlation between Disease Activity and Peripheral Blood Levels of IGF-2 and IGFBP-6 in Patients with Rheumatoid Arthritis[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(3): 427-430.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.03.030 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I3/427

[1] 郭淑芳,姜婷婷. 下调miR-217抑制类风湿性关节炎患者外周血单个核细胞炎症反应的实验研究[J].中国免疫学杂志,2020,36(8):933-938.
[2] 陆光辉,褚志华,曾守逵,等. 类风湿性关节炎患者外周血Nod样受体蛋白3炎症小体和白细胞介素1β表达[J].贵州医科大学学报,2019,44(6):725-729.
[3] 孙怡宁,冯秀媛,曾令霞,等. 炎症、骨重建和类风湿关节炎全身骨量丢失的相关性研究[J].中国骨质疏松杂志,2019,25(5):660-664.
[4] 孙莉,王晓非. IGFBP-6与类风湿关节炎关系的研究进展[J].医学综述,2019,25(11):2109-2114.
[5] KASPRZAK A, ADAMEK A. Insulin-like growth factor 2(IGF2) signaling in colorectal cancer-from basic research to potential clinical applications[J].Int J Mol Sci,2019,20(19):4915.
[6] NEOGI T, JANSEN T L, DALBETH N, et al. 2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative[J].Ann Rheum Dis,2015,74(10):1789-1798.
[7] 赵芬,张爱萍,赵楠楠,等. 类风湿关节炎患者血清IL-27水平及外周血PLR检测与疾病活动度的相关性研究[J].现代检验医学杂志,2019,34(1):34-37.
[8] 杨丽,刘荣华,黄四碧,等. 类风湿性关节炎的发病机制及治疗药物研究进展[J].中国药房,2021,32(17):2154-2159.
[9] LIN Y J, ANZAGHE M, SCHULKE S. Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis[J].Cells,2020,9(4):880.
[10] CHEN Z, BOZEC A, RAMMING A, et al. Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis[J].Nat Rev Rheumatol,2019,15(1):9-17.
[11] CICI D, CORRADO C. Wnt signaling and biological therapy in rheumatoid arthritis and spondyloarthritis[J].Int J Mol Sci,2019,20(22):5552.
[12] POTALITSYN P, SELICHAROVA I, SRSEN K, et al. A radioligand binding assay for the insulin-like growth factor 2 receptor[J].PLoS One,2020,15(9):e238-e239.
[13] ABOALOLA D, HAN V. Insulin-like growth factor binding protein-6 promotes the differentiation of placental mesenchymal stem cells into skeletal muscle independent of insulin-like growth factor receptor-1 and insulin receptor[J].Stem Cells Int,2019,2019:9245938.
[14] TURLO A J, MUELLER-BRECKENRIDGE A J, ZAMBOULIS D E, et al. Insulin-like growth factor binding protein(IGFBP6) is a cross-species tendon marker[J].Eur Cell Mater,2019,38(3):123-136.
[15] 孙莉,王晓非. 胰岛素样生长因子结合蛋白-6在类风湿关节炎患者外周血中的表达及意义[J].中国医科大学学报,2019,48(12):1096-1099.
[16] 陆学丹,余学芳. 血清基质金属蛋白酶2和凝血功能指标在类风湿性关节炎病情活动度监测中的意义[J].安徽医学,2019,40(11):1230-1232.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(3): 448-450.