CT Bhalla评分与COPD合并支气管扩张患者肺功能的相关性

doi:10.3969/j.issn.1671-7171.2023.07.017

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1227 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the correlation between Bhalla score of computed tomography (CT) and pulmonary function in patients with chronic obstructive pulmonary disease (COPD) and Bronchiectasis. 【Methods】The clinical data of 100 patients with COPD admitted to our hospital from January 2021 to January 2022 were retrospectively analyzed. According to whether Bronchiectasis was combined or not, they were divided into a simple COPD group (COPD group, n=65) and a combined Bronchiectasis group (bronchiectasis group, n=35). CT Bhalla scores, lung function indexes (FEV1/FVC, PEF, 6MWT), interleukin-6 (IL-6), interleukin-33 (IL-3), C-reactive protein (CRP), and tumor necrosis factor-α(TNF-α) levels were compared between the two groups; The predictive value of CT Bhalla score, pulmonary function index, IL-6, IL-33, CRP, TNF-α in COPD with Bronchiectasis was analyzed by receiver operating characteristic (ROC) curve; Spearman rank correlation analysis was used to investigate the correlation between lung function indicators, IL-6, IL-33, CRP, TNF-α levels, and CT Bhalla score.【Results】The CT Bhalla score, IL-6, IL-33, CPR and TNF-α levels in the Bronchiectasis group were significantly higher than those in the COPD group, while 6MWT, FEV1/FVC, PEF were lower than those in the COPD group (P<0.05); Receiver operating characteristic analysis confirmed that CT Bhalla score, 6MWT, FEV1/FVC, PEF, IL-6, IL-33, CRP, TNF-α can be used to predict COPD with Bronchiectasis, and the area under the curve was 0.967, 0.906, 0.718, 0.783, 0.582, 0.825, 0.738, 0.745 respectively; The CT Bhalla score was negatively correlated with 6MWT, FEV1/FVC, and PEF (P<0.05), and positively correlated with IL-6, IL-33, CPR, and TNF-α (P<0.05). 【Conclusion】CT Bhalla score is significantly increased in COPD patients with Bronchiectasis, and is closely related to lung function, IL-6, IL-33, CPR and TNF-α levels.

Key words： Pulmonary Disease, Chronic Obstructive/CO Bronchiectasis/CO Tomography, X-Ray Computed Respiratory Function Tests

Received: 28 December 2022

PACS:

R563

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	FAN Rong
	WANG Li-wen

Cite this article:

FAN Rong,WANG Li-wen. Correlation between CT Bhalla Score and Pulmonary Function in COPD Patients with Bronchiectasis[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 1021-1024.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.07.017 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I7/1021

[1] 张力,刘璇,陆沈栋,等. α1-抗胰蛋白酶在稳定期慢性阻塞性肺疾病合并支气管扩张患者血清中的表达及其临床意义[J].医学临床研究,2020,37(2):193-195.
[2] 刘斌,周瑞清,邢青峰. 胸腺肽对COPD合并支气管扩张患者免疫功能的影响[J].中国老年学杂志,2021,41(11):2307-2311.
[3] 邓爱兵,宋健,王静,等. 肺CT联合降钙素原、C反应蛋白检测对COPDⅡ型呼吸衰竭疗效、预后评估的临床价值[J].临床和实验医学杂志,2021,20(2):161-165.
[4] 周洁,翁婷,高蔚. CT Bhalla评分评估支气管扩张患者预后的价值[J].中国医药导报,2021,18(5):121-124.
[5] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南[J].中华结核和呼吸杂志,2002,25(8):453-460.
[6] 成人支气管扩张症诊治专家共识编写组. 成人支气管扩张症诊治专家共识[J].中华结核和呼吸杂志,2012,35(7):485-492.
[7] 曹洪丽,于红,石曼欣妤,等. 支气管肺泡灌洗术联合局部应用敏感抗菌药物对COPD合并支气管扩张患者血气分析、炎症因子及肺功能的影响[J].国际检验医学杂志,2022,43(1):90-93.
[8] 吴玲,梁宗安. 支气管扩张症-慢性阻塞性肺疾病重叠综合征临床特点分析[J].国际呼吸杂志,2020,40(2):87-93.
[9] 蒲豆豆,马军超,于勇,等. 支气管扩张程度的CT定量评估:与人工方法的对照研究[J].放射学实践,2022,37(8):982-986.
[10] 周洁,翁婷,高蔚. CT Bhalla评分评估支气管扩张患者预后的价值[J].中国医药导报,2021,18(5):121-124.
[11] 邹外龙,闫磊,张鑫,等. 支气管扩张症合并慢性阻塞性肺疾病急性加重患者住院死亡的相关因素[J].中华老年多器官疾病杂志,2021,20(8):590-594.
[12] 祁晶,付秀华,王立红,等. 慢性阻塞性肺疾病合并支气管扩张急性加重期肺功能异常的风险因素分析[J].内蒙古医科大学学报,2021,43(4):391-395.
[13] 王萌萌,於海洋,孙雨晴,等. 慢性阻塞性肺疾病患者IL-6、IL-8、TNF-α水平与支气管黏膜自噬的相关性分析[J].临床肺科杂志,2021,26(7):997-1003.
[14] KIM R Y, OLIVER B G, WARK P A B, et al. COPD exacerbations:targeting IL-33 as a new therapy[J].Lancet Respir Med,2021,9(11):1213-1214.
[15] 孙智娜,何秀琴,拉毛卓玛,等.CT Bhalla评分与COPD合并支气管扩张患者肺功能、血气、炎症因子及气道阻力的关系[J].山东医药,2019,59(2):52-54.