Abstract 【Objective】To investigate the correlation between Bhalla score of computed tomography (CT) and pulmonary function in patients with chronic obstructive pulmonary disease (COPD) and Bronchiectasis. 【Methods】The clinical data of 100 patients with COPD admitted to our hospital from January 2021 to January 2022 were retrospectively analyzed. According to whether Bronchiectasis was combined or not, they were divided into a simple COPD group (COPD group, n=65) and a combined Bronchiectasis group (bronchiectasis group, n=35). CT Bhalla scores, lung function indexes (FEV1/FVC, PEF, 6MWT), interleukin-6 (IL-6), interleukin-33 (IL-3), C-reactive protein (CRP), and tumor necrosis factor-α(TNF-α) levels were compared between the two groups; The predictive value of CT Bhalla score, pulmonary function index, IL-6, IL-33, CRP, TNF-α in COPD with Bronchiectasis was analyzed by receiver operating characteristic (ROC) curve; Spearman rank correlation analysis was used to investigate the correlation between lung function indicators, IL-6, IL-33, CRP, TNF-α levels, and CT Bhalla score.【Results】The CT Bhalla score, IL-6, IL-33, CPR and TNF-α levels in the Bronchiectasis group were significantly higher than those in the COPD group, while 6MWT, FEV1/FVC, PEF were lower than those in the COPD group (P<0.05); Receiver operating characteristic analysis confirmed that CT Bhalla score, 6MWT, FEV1/FVC, PEF, IL-6, IL-33, CRP, TNF-α can be used to predict COPD with Bronchiectasis, and the area under the curve was 0.967, 0.906, 0.718, 0.783, 0.582, 0.825, 0.738, 0.745 respectively; The CT Bhalla score was negatively correlated with 6MWT, FEV1/FVC, and PEF (P<0.05), and positively correlated with IL-6, IL-33, CPR, and TNF-α (P<0.05). 【Conclusion】CT Bhalla score is significantly increased in COPD patients with Bronchiectasis, and is closely related to lung function, IL-6, IL-33, CPR and TNF-α levels.
FAN Rong,WANG Li-wen. Correlation between CT Bhalla Score and Pulmonary Function in COPD Patients with Bronchiectasis[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 1021-1024.
2023, Vol. 40 
