特布他林雾化吸入联合有创-无创序贯机械通气治疗重症哮喘合并呼吸衰竭患者的临床疗效

doi:10.3969/j.issn.1671-7171.2023.04.006

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Abstract 【Objective】 To investigate the clinical effect of terbutaline aerosol inhalation combined with invasive-noninvasive sequential mechanical ventilation (ENMV) in the treatment of severe asthma with respiratory failure. 【Methods】 A total of 106 patients with severe asthma complicated with respiratory failure admitted to the Department of Respiratory Medicine of our hospital from January 2019 to January 2022 were selected and divided into the observation group and the control group according to the random number table method,with 53 cases in each group. The control group was treated with ENMV,and the observation group was treated with terbutaline aerosol inhalation on the basis of the control group. We compared the clinical efficacy,length of stay in intensive care unit (ICU),tracheal intubation rate,incidence of ventilator-associated pneumonia (VAP),as well as lung function indicators,blood gas indicators,and inflammatory factor levels before and after treatment between two groups of patients. 【Results】 The total effective rate of the observation group was 88.68%,significantly higher than the control group's 73.58%,with a statistically significant difference (P<0.05). After treatment,the percentage of forced vital capacity in the first second (FEV1%),the ratio of forced expiratory volume in the first second (FEV1) to forced vital capacity (FEV1/FVC),and the maximum expiratory peak flow rate (PEF) in the observation group were significantly higher than those before treatment,and higher than those in the control group. After treatment,the arterial partial pressure of oxygen (PaO₂) and oxygen saturation (SpO₂) in the observation group were significantly higher than those before treatment,and higher than those in the control group; The level of arterial blood partial pressure of carbon dioxide (PaCO₂) was significantly lower than that before treatment,and also lower than that of the control group. After treatment,the tumor necrosis factor (TNF-α),the levels of inflammatory factors such as interleukin-17 (IL-17),interleukin-18 (IL-18),and C-reactive protein (CRP) in the observation group were significantly lower than those before treatment,and even lower than those in the control group. The length of ICU hospitalization in the observation group was significantly shorter than that in the control group (P<0.05),and the tracheal intubation rate was significantly lower than that in the control group (P<0.05); There was no statistically significant difference in the incidence of VAP between the two groups of patients (P>0.05). 【Conclusion】 Terbutaline atomization inhalation combined with ENMV has a significant clinical effect in the treatment of severe asthma with respiratory failure,which can effectively improve the lung function and blood gas indicators of patients,reduce inflammatory reaction,and is worthy of clinical application.

Key words： Asthma/CO Respiratory Insufficiency/CO Asthma/TH Terbutaline/PD Respiration,Artificial

Received: 24 August 2022

PACS:

R562.25

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	XIE Bo
	LI Ning

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XIE Bo,LI Ning. Clinical Efficacy of Terbutaline Aerosol Inhalation combined with Invasive-noninvasive Sequential Mechanical Ventilation in the Treatment of Severe Asthma Complicated with Respiratory Failure[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(4): 500-503.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.04.006 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I4/500

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