Abstract 【Objective】To investigate the predictive value of membrane heparan sulfate proteoglycan ligand-1 (CD138) expression in the endometrium for pregnancy outcome in patients with chronic endometritis (CE) complicated with recurrent implantation failure (RIF). 【Methods】 A total of 126 patients with CE combined with RIF admitted to our hospital from August 2019 to October 2020 were selected as the research objects. Statistics of clinical pregnancy of all subjects were conducted. According to the clinical success of pregnancy,they were divided into success group (59 cases) and failure group (67 cases). The clinical data of patients in the failure and success groups were compared. Logistic multivariate regression analysis of risk factors affecting pregnancy outcomes in CE complicated with RIF patients was performed. Receiver operating characteristic (ROC) curve was prepared,and the area under the curve (AUC) was used to analyze the predictive power of CD138 expression in the endometrium on pregnancy outcomes in patients with CE complicated with RIF. 【Results】The clinical pregnancy failure rate of 126 CE patients with RIF was 53.17%(67/126). The clinical pregnancy rate,continuous pregnancy rate and delivery rate of CD138 positive expression were lower than those of negative expression (P<0.05). The age,luteinizing hormone (LH),follicle-generating hormone (FSH),number of antral follicles,number of transferred embryos,and blastocyst rate in the failure group were lower than those in the successful group (P<0.05),while the proportion of CD138 positive and Histochemical score (H-SCORE) were higher in the successful group (P<0.05). Logistic multivariate analysis showed that the number of embryos transferred,CD138 positive expression,and H-SCORE were independent factors affecting the pregnancy outcome of patients with CE complicated with RIF (OR=2.807,3.089,3.367,P<0.05). The ROC analysis showed that the best cut-off point of the CD138 H-SCORE score in the endometrium for predicting the pregnancy outcome of patients with CE complicated with RIF was 107.43 points,and the AUC was 0.826.【Conclusion】The H-SCORE of CD138 in the endometrium has a high predictive value for the pregnancy outcome of patients with CE complicated with RIF,and can be used as an important reference index to predict the clinical outcome of such patients.
ZHU Jing,LI Hai-xiang,JIANG Sai. Predictive Value of the Expression of CD138 in the Endometrium on the Pregnancy Outcome of Patients with Chronic Endometritis and RIF[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(2): 230-233.
[1] 梁炎春,文扬幸,韦雅婧,等. 慢性子宫内膜炎影响生殖预后的相关机制[J].中国实用妇科与产科杂志,2020,36(12):1214-1218.
[2] 李娜,胡梦迪,王瑛. 体外受精-胚胎移植反复着床失败的影响因素及其与子宫内膜内皮型一氧化氮合酶表达水平的相关性[J].医学临床研究,2022,39(2):191-193.
[3] RIMMER M P,FISHWICK K,HENDERSON I,et al. Quantifying CD138+ cells in the endometrium to assess chronic endometritis in women at risk of recurrent pregnancy loss:A prospective cohort study and rapid review[J].J Obstet Gynaecol Res,2021,47(2):689-697.
[4] 熊玉晶,徐艳文. 不孕症合并慢性子宫内膜炎的诊治[J].中国实用妇科与产科杂志,2020,36(6):488-491.
[5] 陈乐真. 妇产科诊断病理学[M].第2版. 北京:人民军医出版社,2014:23-25.
[6] PARK H J,KIM Y S,YOON T K,et al. Chronic endometritis and infertility[J].Clin Exp Reprod Med,2016,43(4):185-192.
[7] 欧凤柳,胡艳丽. 小剂量雌、孕激素替代疗法对围绝经期综合征患者激素水平、Kupperman评分及子宫内膜厚度的影响[J].中国妇幼保健,2018,33(20):4682-4685.
[8] 沈豪飞,王奕翔,陈华琴,等. 宫腔镜检查对慢性子宫内膜炎的诊断价值[J].中国妇产科临床杂志,2020,21(6):616-617.
[9] HASSANI L H,AMRAOUI F,SPIJKERS L,et al. Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies[J].Sci Rep,2021,11(1):4387.
[10] HECHT J L,KARUMANCHI S A,SHAINKER S A. Immune cell infiltrate at the utero-placental interface is altered in placenta accreta spectrum disorders[J].Arch Gynecol Obstet,2020,301(2):499-507.
[11] 杨静,马彩虹,陶立元,等. 反复着床失败患者慢性子宫内膜炎治疗后妊娠结局改善情况分析[J].中国妇产科临床杂志,2020,21(2):115-118.
[12] 孙迪,杨硕,杨蕊,等. 解冻胚胎移植前CD38、CD138联合筛查慢性子宫内膜炎对妊娠结局的影响[J].中华生殖与避孕杂志,2022,42(7):659-665.
[13] 梁荣丽,罗宋. 慢性子宫内膜炎不孕症患者子宫内膜中CD38、CD138的表达情况分析[J].赣南医学院学报,2019,39(6):590-592.
[1]
. [J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(1): 151-153.
2023, Vol. 40 
