Effects of Dexmedetomidine on Analgesic Effect,Inflammatory Factors and T Lymphocyte Subsets in Patients undergoing TACE Operation for Primary Liver Cancer
LI Jie, ZHANG Yu-he, LI Wei, et al
Yan 'an University Xianyang Hospital,Xianyang Shaanxi 712000
Abstract 【Objective】To investigate the effect of dexmedetomidine on the analgesic effect,inflammatory factors and T lymphocyte subsets of patients undergoing percutaneous transhepatic arterial chemoembolization (TACE) for primary liver cancer. 【Methods】A total of 72 patients with primary liver cancer who were to be treated with TACE were randomly divided into the control group (administration of hydromorphone hydrochloride + tropisetron + saline) and the observation group (administration of hydromorphone hydrochloride + tropisetron + dexmedetomidine),each group had 36 cases of patients.The levels of visual pain simulation score (VAS),inflammatory factors and T lymphocyte subsets were compared between the two groups.Adverse reactions in the two groups of patients during the perioperative period were compared as well. 【Results】There was no significant difference in VAS scores between the two groups of patients before operation (P>0.05).The VAS scores of the two groups of patients at 6 h,12 h and 24 h after surgery were higher than those before surgery (P<0.05).The VAS scores of the observation group at 6 h,12 h and 24 h after operation were lower than those of the control group (P<0.05).At 24 h after surgery,the levels of IFN-γ and TGF-β in the two groups decreased (P<0.05).The levels of IFN-γ and TGF-β at 24 h in the observation group were lower than those in the control group (P<0.05).Compared with preoperatively,serum CD3+,CD4+,CD8+,CD4+/CD8+ ratio all decreased (P<0.05).The CD3+,CD4+,and CD4+/CD8+ ratio of the observation group were higher than those of the control group at 24 h after the operation (P<0.05).There was no difference in the CD8+ levels of the two groups at 24 h after the operation.Statistical significance (P>0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients (P>0.05). 【Conclusion】Dexmedetomidine has a better analgesic effect on patients undergoing TACE for primary liver cancer,which can regulate the level of inflammatory factors and improve the patient's immune function.It is safe and reliable.
LI Jie,ZHANG Yu-he,LI Wei, et al. Effects of Dexmedetomidine on Analgesic Effect,Inflammatory Factors and T Lymphocyte Subsets in Patients undergoing TACE Operation for Primary Liver Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(11): 1615-1617.
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