Abstract 【Objective】To explore the relationship between serum uric acid (UA), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and the onset of Parkinson's disease (PD). 【Methods】A total of 136 PD patients (PD group) and 91 healthy persons (control group) treated in our hospital from January 2019 to August 2020 were collected, and the levels of UA, TG, TC, LDL-C and HDL-C were compared between the two groups; According to Hoehn Yahr (H-Y) stage, PD patients were divided into three subgroups:early stage, middle stage and late stage, and the UA levels of different subgroups were compared; The influencing factors of PD incidence were analyzed by binary logistic regression. 【Results】The levels of UA, TG, TC, LDL-C and HDL-C in the PD group were significantly lower than those in the control group (P<0.05). The UA level in the PD group was significantly lower than that in the control group (P<0.05); There was no significant difference in UA level between women in the PD group and those in the control group (P>0.05). The UA level of PD patients in different stages was significantly different (P<0.05). Binary logistic regression analysis showed that UA and HDL-C levels were correlated with the onset of PD, and high blood UA and HDL-C levels were protective factors for the onset of PD. 【Conclusion】 The levels of UA and HDL-C are related to the pathogenesis of PD.
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(8): 1248-1250.
2022, Vol. 39 
