|
|
|
| Serum Adiponectin, Albumin and Laminin Levels in Patients with Coronary Heart Disease and their Clinical Significance |
| WANG Hai-qiang, WANG Lei |
| No. 986 Hospital of the Chinese People's Liberation Army Air Force,Xi'an Shaanxi 719000 |
|
|
|
|
Abstract 【Objective】 To investigate the levels of serum adiponectin (APN), albumin (ALB) and laminin (LN) in patients with coronary heart disease (CHD) and their clinical significance. 【Methods】 A total of 117 patients with CHD (observation group) admitted to the No.986 Hospital of the Air Force of the Chinese People's Liberation Army Air Force from March 2018 to April 2020 were selected, and 89 healthy volunteers (control group) who underwent physical examination in the same period were selected. 117 patients with CHD were divided into mild disease group (43 cases), moderate disease group (38 cases) and severe disease group (36 cases) according to Gensini score. Enzyme linked immunosorbent assay (ELISA) was used to detect the levels of serum APN, ALB, LN. Pearson correlation analysis was used to analyze the correlation between the levels of serum APN, ALB, LN and Gensini score in patients with CHD. 【Results】Compared with the control group, the levels of serum APN and ALB in the observation group decreased significantly, and the level of serum LN increased significantly (P<0.05). The levels of serum APN and ALB from high to low were mild, moderate and severe lesion groups, and the levels of serum LN from high to low were severe, moderate and mild. The difference between the groups was statistically significant (P<0.05). The Gensini score of CHD patients was (43.64±13.76), the levels of serum APN and ALB were negatively correlated with Gensini score, and the level of LN was positively correlated with Gensini score (P<0.05). 【Conclusion】The low expression of APN and ALB and high expression of LN in serum of CHD patients may be related to the severity of CHD.
|
|
Received: 15 December 2021
|
|
|
|
|
|
[1] 曾苗雨,易旦冰,陈晓亮,等. 64层螺旋CT冠状动脉支架成像与冠状动脉造影诊断再狭窄的价值分析[J].中国CT和MRI杂志,2015,13(5):60-62.
[2] 韦传东,王迪,向晓华. 脂联素及其受体在心血管疾病作用的研究进展[J].右江医学,2019,47(5):384-387.
[3] 李建红,柴艳芬,曹超. 血清白蛋白联合急诊脓毒症死亡风险评分对脓毒症患者预后价值的研究[J].中华临床医师杂志(电子版),2016,10(8):76-80.
[4] 刘鲜艳,郝斌威,马爱玲,等. 不同抗原修复方法对层黏连蛋白免疫组化染色结果的影响[J].临床与实验病理学杂志,2015,31(2):216-217.
[5] ANIL A,SERDAR F,MUSTAFA T M,et al. Association between the gensini score and carotid artery stenosis[J].Korean Circ J,2016,46(5):639-645.
[6] 徐玲,尹婷婷,俞吉,等. 冠心病冠状动脉粥样硬化发生的危险因素多因素Logistic分析[J].临床和实验医学杂志,2019,18(6):626-629.
[7] MALAKAR A K,CHOUDHURY D,HALDER B,et al. A review on coronary artery disease,its risk factors and therapeutics[J].J Cell Physiol,2019,234(10):16812-16823.
[8] 史际华,崔建娇. 冠心病患者CTRP9、APN、SAA、hs-CRP水平与冠脉斑块稳定性的相关性[J].中国老年学杂志,2018,38(14):3365-3368.
[9] 钱新宇,吕金峰,MUHAMMAD B,等. 急性脑梗死静脉溶栓后早期神经功能恶化与血清白蛋白水平的关系研究[J].中国医师进修杂志,2019,42(4):318-324.
[10] AUMAILLEY M. Isolation and analysis of laminins[J].Methods Cell Biol,2018,143(11):187-205.
[11] MALTSEVA D V,RODIN S A. Laminins in Metastatic Cancer[J].Mol Biol,2018,52(3):350-371.
[12] 刘梦平,刘宝奇. 血清透明质酸、层粘连蛋白对CHD患者并发心肌梗死的诊断意义[J].中国生化药物杂志,2017,37(7):374-376. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(8): 1248-1250. |
|
|
|
|
2022, Vol. 39 
