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| Clinical Study of Helleborusthibetanus Franch Polysaccharide (HFPS) Combined with Endocrine Therapy for Advanced Prostate Cancer |
| CHENG Lu, ZENG Zhao-chang, LIU Yuan-ling, et al |
| Huadu District People's of Guangzhou,Guangzhou Guangdong 510800 |
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Abstract 【Objective】 To investigate the clinical efficacy of Helleborusthibetanus Franch polysaccharide (HFPS) combined with endocrine therapy for advanced prostate cancer and its inhibitory effect on prostate cancer cells. 【Methods】 The clinical data of 154 patients with advanced prostate cancer treated in our hospital were retrospectively analyzed. According to the different treatment methods, they were divided into control group (endocrine therapy) and observation group ( Helleborusthibetanus Franch combined with endocrine therapy), with 77 cases in each group. The levels of prostate-specific antigen (PSA) and free prostate-specific antigen (F-PSA) were compared between the two groups before and after treatment. The quality of life and international prostate cancer symptom scale (I-PSS) scores of the two groups were compared, and the effects of different doses of HFPS on DU145 cell cycle were compared. 【Results】After treatment, the levels of PSA and F-PSA in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05); The QLQ-C30 and I-PSS scores of the two groups were lower than those before treatment, and the observation group was lower than that of the control group, the difference was statistically significant (P<0.05). The proportion of G0/G1 cells in the high-dose group was significantly lower than that in the control group and low-dose group (P<0.05); The proportion of S-phase cells in the high-dose group and the low-dose group was significantly higher than that in the control group, and that in the low-dose group was higher than that in the control group (P<0.05). The incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). 【Conclusion】 Helleborusthibetanus Franch polysaccharide (HFPS)combined with endocrine therapy has a good clinical effect on advanced prostate cancer, and Helleborusthibetanus Franch polysaccharide can better inhibit prostate cancer cells.
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Received: 14 May 2022
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2022, Vol. 39 
