大剂量羟考酮缓释片在晚期消化系统肿瘤中重度疼痛患者中的应用效果

doi:10.3969/j.issn.1671-7171.2022.06.030

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Abstract 【Objective】To explore the application effect of high-dose oxycodone sustained-release tablets in moderate and severe pain in patients with advanced digestive system tumors.【Methods】 The clinical data of 60 patients with moderate and severe pain of advanced digestive system tumors treated in the oncology department of Xi'an Fouth Hospital from January 2017 to April 2020 were analyzed retrospectively. The patients in the control group were treated with conventional dose of oxycodone sustained-release tablets (the initial dose was 10 mg/therapy),and the patients in the observation group were treated with high-dose oxycodone sustained-release tablets (the initial dose was 40 mg/therapy). The changes of pain degree (NRS),immune function [T cell subsets (CD3⁺,CD4⁺,CD8⁺) and natural killer cells (NK)],anxiety and depression (SAS/SDS),coping style (Medical Coping Questionnaire,MCMQ) and adverse reactions were compared between the two groups. 【Results】Before treatment,there was no significant difference in NRS score,CD3⁺,CD4⁺,CD8⁺,CD4⁺/CD8⁺,NK cell level,SAS,SDS score,yield,escape and face score in MCMQ between the two groups (P>0.05); After treatment,the NRS scores,CD3⁺,CD4⁺,CD4⁺/CD8⁺,NK cell levels,SAS,SDS scores,yield and escape scores of the two groups were significantly lower than those before treatment (P<0.05); The level of CD8⁺ was significantly higher than that before treatment,and the NRS score,CD3⁺,CD4⁺, CD4⁺/CD8⁺,NK cell level,SAS,SDS score,yield and escape score of the observation group were significantly lower than those of the control group (P<0.05),and the level of CD8⁺ was higher than that of the control group (P<0.05). 【Conclusion】High dose oxycodone sustained release tablets can effectively alleviate the pain of patients with moderate and severe pain in advanced digestive system tumors,enhance immune function,reduce the degree of anxiety and depression,and the safety is not affected.

Key words： Digestive System Neoplasms/CO Pain/DT Oxycodone/TU

Received: 14 December 2021

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	GUO Zheng-she
	HE Yin-bin

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GUO Zheng-she,HE Yin-bin. Application of High-Dose Oxycodone Sustained-Release Tablets in Moderate and Severe Pain in Patients with Advanced Digestive System Tumors[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 913-916.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.06.030 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I6/913

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