重症肺炎支原体肺炎患儿血清FIB、TSP-1水平及其与患儿预后的相关性

doi:10.3969/j.issn.1671-7171.2022.06.029

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1139 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the serum levels of human fibrinogen (FIB) and platelet reactive protein-1 (TSP-1) in children with severe Mycoplasma pneumoniae pneumonia (MPP),and to analyze their correlation with prognosis. 【Methods】 A total of 80 children with severe MPP (severe group) and 80 children with mild MPP were selected as the mild group. According to the prognosis of the children,the children with severe MPP were divided into the improvement group (n=53) and the deterioration group (n=27). The levels of FIB and TSP-1 in serum were detected by enzyme-linked immunosorbent assay. The correlation between FIB and TSP-1 levels and pneumonia severity index (PSI) was analyzed by Pearson method. The predictive value of FIB and TSP-1 in serum for the poor prognosis of children with severe MPP was analyzed by ROC curve.【Results】Compared with the mild MPP group,the platelet count (PLT),mean platelet volume (MPV),D-dimer,antithrombin Ⅲ (AT-Ⅲ),white blood cell count (WBC),neutrophil count (NEU),lactate dehydrogenase (LDH),erythrocyte sedimentation rate (ESR),C-reactive protein (CRP) and PSI score in the severe MPP group were significantly higher (P<0.05). The levels of serum FIB and TSP-1 in the severe group were significantly higher than those in the mild group (P<0.05). The expression levels of FIB and TSP-1 in serum of children with severe MPP were positively correlated with PSI score (P<0.05). The expression levels of FIB,TSP-1 and PSI score in the MPP group and the deterioration group were significantly higher than those in the mild MPP group (P<0.05). The sensitivity,specificity and area under the curve were 88.89%,81.13% and 0.920 respectively.【Conclusion】The levels of serum FIB and TSP-1 in children with severe MPP are significantly increased,which is related to the severity of the disease,and may be used as a potential marker to predict the poor prognosis of children with severe MPP.

Key words： Pneumonia, Mycoplasma Fibrinogen/BL Thrombospondin 1/BL Prognosis

Received: 22 December 2021

PACS:

R725.631

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	GAO Shi-yue
	CAO Ya-min

Cite this article:

GAO Shi-yue,CAO Ya-min. Serum FIB,TSP-1 Levels in Children with Severe Mycoplasma Pneumonia and their Correlation with Prognosis[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 909-912.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.06.029 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I6/909

[1] LUO J,YU H,HU Y H,et al. Early identification of patients at risk for acute respiratory distress syndrome among severe pneumonia:a retrospective cohort study[J].J Thorac Dis,2017,9(10):3979-3995.
[2] 杜江滨,王健,蔡泽波,等. 重症肺炎患儿凝血指标、血小板参数测定的临床意义[J].临床肺科杂志,2017,22(1):142-144.
[3] CHOI S T,SONG J S. Serum procalcitonin as a useful serologic marker for differential diagnosis between acute gouty attack and bacterial infection[J].Yonsei Med J,2016,57(5):1139-1144.
[4] MENEGAZZO L,ALBIERO M,MILLIONI R,et al. Circulating myeloid calcifying cells have antiangiogenic activity via thrombospondin-1 overexpression[J].FASEB J,2013,27(11):4355-4365.
[5] 赵新玲,陶然,杨园,等. 血小板反应蛋白1(THBS-1)与急性缺血性脑卒中诊断和预后的相关性研究[J].华中科技大学学报(医学版),2018,47(5):88-92.
[6] 中华医学会儿科学分会呼吸学组,《中华实用儿科临床杂志》编辑委员会. 儿童肺炎支原体肺炎诊治专家共识(2015年版)(上)[J].中华实用儿科临床杂志,2015,30(17):1304-1308.
[7] 中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童社区获得性肺炎管理指南(2013修订)[J].中华儿科杂志,2013,51(10):745-752.
[8] 郭伟,张同强,徐勇胜. 肺炎支原体肺炎患儿 TNF-α、IFN-γ和 IL-4 细胞因子水平的变化[J].中国现代医学杂志,2018,28(23):65-68.
[9] 李丹,潘家华. 儿童社区获得性重症肺炎的诊断与治疗[J].中华全科医学,2016,14(10):1611-1612.
[10] 田鑫. 重症肺炎患者血清中sTREM-1、纤维蛋白原及D-二聚体水平变化及临床意义[J].临床肺科杂志,2018,23(9):155.
[11] 沈逍雁,斯明强.中性粒细胞弹性蛋白酶和纤维蛋白原联合肿瘤坏死因子-α在预测儿童重症肺炎预后中的应用价值[J].中国中西医结合急救杂志,2019,26(2):147-151.
[12] MIAO X,RAHMAN M F,JIANG L,et al. Thrombin-reduced miR-27b attenuates platelet angiogenic activities in vitro via enhancing platelet synthesis of anti-angiogenic thrombospondin-1[J].J Thromb Haemost,2018,16(4):791-801.
[13] LOPEZ-RAMIREZ M A,FONSECA G,ZEINEDDINE H A,et al.Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations[J].J Exp Med,2017,214(11):3331-3346.
[14] 白洁明,徐超,刘羽,等. 血小板反应蛋白-1对多囊卵巢综合征大鼠血清内分泌腺来源血管内皮生长因子及卵巢组织形态学的影响[J].中华实用诊断与治疗杂志,2019,33(11):1053-1057.
[15] TALME T,BERGDAHL E,SUNDQVIST K G. Methotrexate and its therapeutic antagonists caffeine and theophylline,target a motogenic T-cell mechanism driven by thrombospondin-1 (TSP-1)[J].Eur J Immunol,2016,46(5):1279-1290.