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| Expression of MLF1IP in Bladder Urothelial Carcinoma and its Clinical Significance |
| ZHANG Zhi-guo, KANG Wen-yu |
| Xi'an Baoshihua Changqing Hospital, Xi'an Shaanxi 710201, China |
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Abstract 【Objective】To investigate the expression of human myeloid leukemia factor 1-interacting protein gene (MLF1IP) in patients with bladder urothelial carcinoma. 【Methods】A total of 52 patients with bladder urothelial carcinoma who underwent surgery in our hospital from February 2015 to February 2017 were selected. The resected cancer tissues and adjacent normal tissues were taken and divided into bladder urothelial carcinoma group (observation group) and adjacent group (control group). The expression levels of MLF1IP mRNA and MLF1IP in adjacent tissues and cancer tissues of all subjects were detected, the relationship between MLF1IP mRNA expression level and clinicopathological features of bladder urothelial carcinoma was analyzed, the effect of MLF1IP mRNA expression level on the prognosis of patients with bladder urothelial carcinoma was evaluated, and the related factors affecting the prognosis of patients with bladder urothelial carcinoma were analyzed. 【Results】The positive expression rate of MLF1IP, MLF1IP mRNA and MLF1IP level in the observation group were significantly higher than those in the control group (P<0.05). The expression of MLF1IP mRNA in patients with bladder urothelial carcinoma was related to the pathological grade and clinical stage of bladder urothelial carcinoma (P<0.05), but not to the patient's gender, age and tumor diameter (P>0.05). The 3-year overall survival rate of patients with high expression of MLF1IP mRNA was lower than that of patients with low expression of MLF1IP mRNA (P<0.05). The high expression of MLF1IP mRNA and pathological grade were independent risk factors affecting the prognosis of patients with bladder urothelial carcinoma (P<0.05). 【Conclusion】The high expression of MLF1IP in patients with bladder urothelial carcinoma is related to the pathological grade, clinical stage and prognosis. It is of great significance to evaluate the prognosis of patients.
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Received: 05 December 2021
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2022, Vol. 39 
