Abstract 【Objective】 To investigate the effect of soluble growth stimulating factor 2 (sST2) on the prognosis of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). 【Methods】A total of 132 patients with AMI treated in our hospital from January 2019 to December 2020 was selected. According to the prognosis after PCI, they were divided into poor prognosis group (n=29) and good prognosis group (n=103). The clinical data of the two groups were compared, the levels of ST2 in patients with different Killip cardiac function grades were compared, the diagnostic value of ST2 in the diagnosis of poor prognosis after PCI in patients with AMI was analyzed, and the clinical factors affecting the poor prognosis were analyzed by COX risk regression model. 【Results】The time of chest pain and the levels of cTnI, ST2 and LDL-C in the poor prognosis group were higher than those in the good prognosis group, and LVEF was lower than those in the good prognosis group (P<0.05). The level of ST2 in Killip grade Ⅲ and Ⅳ patients was (28.04±7.52) ng/mL, which was significantly higher than that in Killip grade Ⅰ and Ⅱ (19.37±4.14) ng/mL(t=8.147, P<0.01). ROC curve evaluation of the value of ST2 in the diagnosis of poor prognosis in patients with AMI showed that the area under the diagnostic value curve (AUC) (95%CI) was 0.78 (0.67~0.88). COX risk regression model analysis showed that cTnI and ST2 were independent risk factors for poor prognosis in patients with AMI (P<0.05), and LVEF was a protective factor for poor prognosis in patients with AMI (P<0.05). 【Conclusion】ST2 is a potential clinical index to affect and evaluate the poor prognosis of AMI patients after PCI.
WANG Rui,ZENG Xin-chun. Effect of Soluble Growth Stimulating Factor 2 on Prognosis of AMI Patients after PCI[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(2): 278-280.
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