血管性痴呆患者血清IGF-1、IGFBP-3表达水平与认知损害的相关性分析

doi:10.3969/j.issn.1671-7171.2022.02.032

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Abstract 【Objective】To investigate the expression levels of IGF-1 and IGFBP-3 in serum of patients with vascular dementia (VD) and their relationship with cognitive impairment. 【Methods】From January 2018 to January 2020, 63 patients with VD admitted to our hospital were selected as VD group, and they were further divided into the mild VD group (15 cases), moderate VD group (26 cases) and severe VD group (22 cases) according to Mini-mental state examination (MMSE) score. Another 60 cases of healthy volunteers without VD in our hospital during the same period were selected as normal control group. The expression levels of IGF-1 and IGFBP-3 were detected by ELISA; Pearson method was used to analyze the correlation of serum IGF-1 and IGFBP-3 expression levels with the Montreal cognitive assessment scale (MoCA) score. Logistic regression model was used to analyze the influencing factors of VD. 【Results】The expression levels of serum IGF-1 and IGFBP-3, and scores of MOCA and MMSE in the VD group were lower than those in the control group (P<0.05). The levels of serum IGF-1 and IGFBP-3 in patients with VD mild group, moderate group and severe group were significantly decreased in turn (P<0.05). The expression levels of IGF-1 and IGFBP-3 were positively correlated with MoCA score (P<0.05). Low MMSE score, low MoCA score, low level of IGF-1 and low level of IGFBP-3 were risk factors for VD(P<0.05). 【Conclusion】The levels of serum IGF-1 and IGFBP-3 in VD patients are significantly decreased, and they are closely related to the degree of cognitive impairment, which could be used as serum indicators to evaluate the occurrence of VD.

Key words： Dementia,Vascular Insulin-Like Growth Factor I Insulin-Like Growth Factor Binding Protein 3 Cognition

Received: 17 December 2021

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R741

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	SU Hang
	JIANG Xing-wen

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SU Hang,JIANG Xing-wen. Correlation Analysis of Cognitive Impairment with Serum IGF-1 and IGFBP-3 Expression in Patients with Vascular Dementia[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(2): 274-277.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.02.032 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I2/274

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