Abstract 【Objective】To explore the effect of Qishiyishen Recipe on renal function and podocyte markers in patients with chronic glomerulonephritis. 【Methods】 A total of 130 patients with chronic glomerulonephritis treated in our hospital were divided into control group and observation group according to their admission number, with 65 cases in each group. The control group was treated with routine treatment, and the observation group was treated with Qishiyishen recipe. The indexes of renal function, cellular immune function and the levels of podocyte markers [podocyte marker protein (PCX) and transmembrane protein B7-1] were compared between the two groups before and after treatment. 【Results】 Before intervention, there was no significant difference in renal function, cellular immune function and podocyte markers between the two groups (P>0.05). After the intervention, the indexes of urinary nitrogen, 24h urinary protein and blood creatinine in the two groups were lower than those before the intervention (P<0.05), and those in the observation group were lower than those in the control group (P<0.05); The levels of CD4+, CD4+/CD8+ in the two groups were higher than those before the intervention (P<0.05), and that in the observation group was higher than that in the control group (P<0.05). The levels of CD8+ in the two groups were lower than those before the intervention (P<0.05), and that in the observation group was lower than that in the control group (P<0.05). The contents of urinary PCX and urinary B7-1 in the two groups were lower than those before intervention (P<0.05), and those in the observation group were lower than those in the control group (P<0.05). 【Conclusion】The application of Qishiyishen recipe in the treatment of chronic glomerulonephritis can improve the level of renal function, correct the imbalance of T lymphocyte subsets, improve cellular immune function and reduce the damage of immune inflammation to podocytes.
ZHAO Wen-ge,FAN Xiong. Effect of Qishiyishen Recipe on Renal Function and Podocyte Markers in Patients with Chronic Glomerulonephritis[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(2): 229-231.
[1] 王园园,祝佩,王赟.层级管理模式在慢性肾脏病患者健康管理中的应用[J].齐鲁护理杂志,2020,26(5):92-95. [2] 艾年年,李章晗,黎华茂.益气消肿饮合穴位埋线治疗肾病综合征顽固性水肿疗效及对肾小管损害标志物,炎性细胞因子的影响[J].现代中西医结合杂志,2020,29(33):67-70. [3] 杨盼,李珺,岳艳利,等.实脾固肾化瘀方对慢性肾脏病患者炎症因子及瘦素水平的影响[J].中医药学报,2019,47(1):81. [4] LI L, CUI H, LI T. Synergistic effect of berberine-based chinese medicine assembled nanostructures on diarrhea-predominant irritable bowel syndrome in vivo[J].Front Pharmacol, 2020,31(11):1210-1213. [5] 张翠薇,马程功,文雪,等. 固本化瘀通络合剂含药血清对高糖诱导的足细胞损伤影响及机制研究[J].中华中医药学刊,2019(7):1608-1611. [6] 陈嘉文,王晓光.固本通络祛风方辅助治疗脾肾两虚型慢性肾小球肾炎的疗效及对肾纤维化程度、全身炎性反应的影响[J].世界中医药,2019,14(8):2063-2066. [7] 孙怡婕,肖婧,张栩.知柏清凉方对老年慢性肾小球肾炎患者尿蛋白定量,CysC及血sFlt-l的影响[J].老年医学与保健,2019,25(3):38-42. [8] CHEN Z. Network pharmacology based research into the effect and mechanism of Yinchenhao Decoction against Cholangiocarcinoma[J].Chin Med,2021,16(1):13-16. [9] YU X H.Yangxin Decoction combined acupuncture on blood lipid metabolism in Qi Deficiency and Blood Stasis type of Chest Bi-Syndrome: A protocol of systematic review[J].Medicine (Baltimore),2020,99(34):217-221. [10] 茅燕萍,王亿平,陈成,等.参地颗粒对慢性肾小球肾炎脾肾亏虚证患者细胞毒T淋巴细胞相关抗原-4/外周单个核细胞B7-1介导的免疫炎症紊乱的影响[J].广州中医药大学学报, 2019,11(2):165-170. [11] 韩永生.补气逐瘀方辅治气虚血瘀型慢性肾炎的效果及对中医症候、肾功能、血清炎症因子和TIMP-1、MMP-9水平的影响[J].四川中医,2020,38(2):118-121. [12] 杨敬,郑劲,钟锦,等.补肾清利活血汤对慢性肾小球肾炎患者肾功能及炎症状态的影响[J].中国中西医结合肾病杂志,2020,21(2):63-65. [13] 陈腾.黄芪治疗糖尿病肾病临床疗效及对尿足细胞标志蛋白影响[J].中国中西医结合肾病杂志,2019,20(8):44-46.
[1]
. [J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(1): 111-113.
2022, Vol. 39 
