无卒中患者脑小血管病总负荷与颅内外动脉硬化的相关性研究

doi:10.3969/j.issn.1671-7171.2022.01.004

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Abstract 【Objective】To investigate the correlation and clinical characteristics between imaging markers and total load of cSVD and the degree of extracranial and extracranial arteriosclerosis in patients without stroke. 【Methods】The clinical features, carotid ultrasound, magnetic resonance imaging (MRI) and computed tomography angiography (CTA) of 200 stroke-free patients were collected. The total load score of cSVD imaging markers was performed. The degree of extracranial and intracranial arteriosclerosis was evaluated according to the scores of extracranial and intracranial arteriosclerosis; The baseline data and extracranial and extracranial arteriosclerosis scores of patients with different global cSVD total load scores were compared; The correlation between various cSVD imaging marker scores, cSVD total load score and extracranial and extracranial arteriosclerosis score was analyzed. 【Results】There were significant differences in age, high homocysteine, intracranial artery stenosis, carotid plaque, intracranial arteriosclerosis score, extracranial arteriosclerosis score and total extracranial and extracranial arteriosclerosis score among patients with different total cerebral cSVD load score (P<0.01). The whole brain cSVD total load score was positively correlated with the total scores of extracranial, intracranial and extracranial arteriosclerosis (r_s=0.594, 0.401 and 0.535, respectively, P<0.01); The correlation between cSVD total load score in one hemisphere and ipsilateral extracranial, intracranial and extracranial arteriosclerosis scores was significantly greater than that with contralateral extracranial, intracranial and extracranial arteriosclerosis (ipsilateral r_s=0.616, 0.465 and 0.612, and contralateral r_s=0.495, 0.355 and 0.478, respectively, P<0.01). Except for the PVSs score in the semioval center, the scores of other cSVD imaging markers were positively correlated with the total scores of extracranial, intracranial and extracranial arteriosclerosis.【Conclusion】The more severe the intracranial and extracranial arteriosclerosis, the heavier the ipsilateral and whole brain cSVD load; Extracranial and extracranial arteriosclerosis was positively correlated with the degree of lesions of various cSVD except PVSs in the center of semioval.

Key words： Cerebral Small Vessel Diseases Intracranial Arteriosclerosis

Received: 07 June 2021

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R743

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.01.004 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I1/13

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