医学临床研究
   Jun. 12, 2025    Home  |  About Journal  |  Editorial Board  |  Instruction  |  Subscribe  |  Advertisement  |  Messages Board  |  Contact Us  |  中文
JOURNAL OF CLINICAL RESEARCH  2021, Vol. 38 Issue (11): 1632-1634    DOI: 10.3969/j.issn.1671-7171.2021.11.009
Original Article Current Issue | Archive | Adv Search |
Value of Combined Quantitative Diagnosis of Pet/Ct Metabolic Parameters in Predicting the Risk of Lymph Node Metastasis in Breast Cancer Patients
QIAN Li-xin, QIN Dong-jie
Imaging Department, Wuxi People's Hospital,Wuxi Jiangsu 214023
Download: PDF (1200 KB)   HTML (1 KB) 
Export: BibTeX | EndNote (RIS)      
Abstract  【Objective】To explore the value of positron emission tomography (PET/CT) combined with metabolic parameters in quantitative diagnosis and prediction of lymph node metastasis risk in breast cancer patients. 【Methods】A total of 78 patients with breast cancer admitted to our hospital were enrolled in the study. All patients underwent PET/CT examination and sentinel lymph node (SLN) biopsy before treatment. According to the results of SLN biopsy, 47 patients who showed SLN positive were divided into the metastatic group (n=42) and 6 patients were in the non-metastatic group .The differences of the maximum standard uptake of PET/CT metabolic parameters (SUVmax), tumor metabolic volume (MTV) and total glycolysis (TLG) between the two groups were compared, and the value of PET/CT metabolic parameters in predicting the risk of lymph node metastasis in breast cancer patients was analyzed by ROC. 【Results】SUVmax, MTV and TLG in the metastatic group were significantly higher than those in the non-metastatic group (P<0.05).ROC analysis confirmed that SUVmax, MTV and TLG could all be used to predict the risk of lymph node metastasis in adenocarcinoma patients, and the areas under the curve were 0.901, 0.678 and 0.871, respectively, with P<0.05.The sensitivity, specificity, accuracy, positive predictive value, negative predictive value and Kappa for the combined diagnosis of PET/CT metabolic parameters in predicting the risk of lymph node metastasis in breast cancer patients were 0.857, 0.944, 0.897, 0.897, 0.947 and 0.795 respectively. 【Conclusion】PET/CT metabolic parameters SUVmax≥5.475, MTV≥8.155 cm3, and TLG≥ 22.63 g can be used to predict the risk of lymph node metastasis in breast cancer patients, and furthermore the three parameters combined diagnosis has a higher sensitivity to predict the risk of lymph node metastasis, which is worthy of clinicians' attention.
Key wordsBreast Neoplasms      Lymphatic Metastasis/DG      Tomography, Spiral Computed      Positron-Emission Tomography     
Received: 21 July 2021     
PACS:  R737.9  
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
QIAN Li-xin
QIN Dong-jie
Cite this article:   
QIAN Li-xin,QIN Dong-jie. Value of Combined Quantitative Diagnosis of Pet/Ct Metabolic Parameters in Predicting the Risk of Lymph Node Metastasis in Breast Cancer Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(11): 1632-1634.
URL:  
http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.11.009     OR     http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I11/1632
Copyright © Editorial Board of JOURNAL OF CLINICAL RESEARCH
Supported by:Beijing Magtech