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| A 3-year Follow-up Observation of Repeated Wheezing in Children under 5 Years Old |
| GU Xiu-ming, DONG Wei, ZHANG Lan, et al |
| Department of Pediatrics, Nanxiang Hospital, Jiading District, Jiading 201802, Shanghai |
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Abstract 【Objective】To investigate the onset, outcome and risk factors from 3-year follow-up of repeated wheezing in children under 5 years old. 【Methods】A total of 147 children under the age of 5 who were admitted to the Department of Pediatrics of our hospital due to recurrent wheezing were selected and followed up 3 years. According to the age of onset and remission of wheezing, the children were divided into transient wheezing group, persistent wheezing group and late-onset wheezing group. The general information, allergy-related indicators, and wheezing onset age of the three groups were compared. And the related risk factors of children with repeated wheezing were analyzed. 【Results】There was no significant difference in the number of wheezing among the three groups of children in the past 1 year when they were admitted to the hospital and the number of wheezing in the past 1 year during the follow-up (P>0.05). Children with transient wheezing did not relapse. However, the number of wheezing in the one-year follow-up in the persistent wheezing group and the late-onset wheezing group was significantly less than the number of wheezing in the past one year at admission (P<0.05).At admission, total virus positive, rhinovirus (RV) positive and respiratory syncytial virus (RSV) positive in the three groups of children were not significant (P>0.05). The previous rhinitis rates in the persistent wheezing group and late-onset wheezing group were significantly higher than that in the transient wheezing group (P<0.05),however, there was no significant difference between the persistent and late-onset wheezing group (P>0.05). The comparison of the three groups of children with the history of eczema and parental asthma did not show significant (P>0.05). The comparison of total allergen IgE was not significant (P>0.05). The serum allergen IgE of the transient wheeze group was significantly lower than that of the persistent wheezing group and the late-onset wheezing group (P<0.05),but there was no significant difference between the persistent wheeze group and the late-onset wheeze group (P> 0.05). Among the three groups of children, the positive rates of inhaled allergens and the percentage of peripheral blood eosinophils (EOS) counts from high to low were in order of transient wheeze group, persistent wheeze group to late-onset wheeze group. The differences were significant (P<0.05). However, the absolute count of EOS in the peripheral blood was not significant among three groups (P>0.05). Eczema, parental allergic rhinitis or asthma, passive smoking, viral infection, and mycoplasma infection were the main risk factors for wheezing in children. 【Conclusion】With the increase of age, the incidence of wheezing in children decreases significantly, and the outcome of wheezing is significantly correlated with allergies and rhinitis.
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Received: 20 December 2020
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2021, Vol. 38 
