LncRNA MINCR表达对失代偿期肝硬化患者预后的评估价值

doi:10.3969/j.issn.1671-7171.2021.05.016

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Abstract 【Objective】 To investigate the prognostic value of expression of LncRNA MINCR in patients with decompensated cirrhosis. 【Methods】 From January 2017 to January 2018, 120 patients with decompensated cirrhosis were selected and divided into survival group and death group according to the follow-up survival status. The relative expression of LncRNA MINCR was detected by real-time fluorescence quantitative polymerase chain reaction (qRT-PCR). Pearson method was used to analyze the correlation between LncRNA MINCR and the clinical characteristics of patients with cirrhosis. ROC was used to analyze the diagnostic performance of each index for the prognosis of decompensated cirrhosis. Cox regression analysis was used to analyze the independent risk factors influencing the prognosis of patients. 【Results】 Pearson analysis showed that the expression level of LncRNA MINCR was positively correlated with TBIL, INR, CTP and MELD (P<0.05), but not with ALB, Cr and Na (P>0.05). ROC curve analysis showed that the best critical point of LncRNA MINCR for predicting death in patients with cirrhosis was 2.32, the sensitivity was 96.71%, the specificity was 90.50%, and the area under AUC curve was 0.973. Multivariate Cox regression analysis showed that LncRNA MINCR was an independent risk factor for death in decompensated cirrhosis (HR:1.13;95%CI:1.07-1.19). 【Conclusion】 LncRNA MINCR has a certain value in judging the condition and prognosis of patients with decompensated cirrhosis. The method is simple and easy to use, which is worth popularizing.

Key words： Liver Cirrhosis /PP Liver Cirrhosis /TH Treatment Outcome

Received: 29 September 2020

PACS:

R575.2

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	ZHANG Xue-yan
	WU Jian-ping

Cite this article:

ZHANG Xue-yan,WU Jian-ping. Prognostic Value of Expression of LncRNA MINCR in Patients with Decompensated Cirrhosis[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(5): 694-697.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.05.016 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I5/694

[1] 中华医学会肝病学分会. 肝硬化腹水及相关并发症的诊疗指南[J].临床肝胆病杂志,2017,33(10):158-174.
[2] D'AMICO G,GARCIA-TSAO G,PAGLIARO L . Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies[J].J Hepatol,2006, 44(1):217-231.
[3] 徐小元,丁惠国,李文刚,等.肝硬化诊治指南[J].临床肝胆病杂志,2019,35(11):2408-2425.
[4] 赵志国, 张力平. miRNA和lncRNA相互作用与恶性肿瘤相关性的研究进展[J].现代肿瘤医学, 2018,26(18):2991-2994.
[5] 曹金玉. 长链非编码RNA MINCR调控肝细胞肝癌增殖迁移和侵袭[D].南昌大学,2018.
[6] 中国中西医结合学会消化系统疾病专业委员会.肝硬化中西医结合诊疗共识[J].中国中西医结合消化杂志,2011,19:277-279.
[7] FORTUNE B E,GARCIA-TSAO G,Maria C,et al. Child-turcotte-pugh class is best at stratifying risk in variceal hemorrhage[J].J Clin Gastroenterol,2017, 51(5):446-453.
[8] KAMATH P S,WIESNER R H,MALINCHOC M,et al. A model to predict survival in patients with end-stage liver disease[J].Hepatology,2001, 33(2):464-470.
[9] 中华医学会感染病学分会,中华医学会肝病学分. 慢性乙型肝炎防治指南(2019年版)[J].临床肝胆病杂志.2019.35(12):2648-2669.
[10] RAMANATHAN S,KHANDELWAL N,KALRA N,et al. Correlation of HVPG level with CTP score, MELD score, ascites, size of varices, and etiology in cirrhotic patients[J].Saud J Gastroenterol,2015, 22(2):109-115.
[11] 吴吉圆, 张冬琴, 刘菲菲, 等. 病毒性肝炎肝硬化失代偿期患者评分系统对短期预后的分析[J].中国肝脏病杂志(电子版), 2017,9(1):54-58.
[12] 梁利民, 徐鹤翔, 郑吉顺,等. 中性粒细胞与淋巴细胞比值对失代偿期肝硬化患者预后的评估价值[J].临床肝胆病杂志, 2019, 35(04):96-101.
[13] 王昀,杨永成.肝脏面积与腹部面积比评估失代偿期肝硬化患者预后的价值[J].中国肝脏病杂志(电子版),2019,11(03):47-51.
[14] SHACHAF C M . Tumor dormancy and MYC inactivation: pushing cancer to the brink of normalcy[J].Cancer Res,2005, 65(11):4471-4474.
[15] WANG S H,YANG Y,WU X C,et al. Long non-coding RNA MINCR promotes gallbladder cancer progression through stimulating EZH2 expression[J].Cancer letters,2016, 380(1):122-133.
[16] LIAN J,ZHANG X,LU Y,et al. Expression and significance of LncRNA-MINCR and CDK2 mRNA in primary hepatocellular carcinoma[J].Comb Chem High Throughput Screen, 2019, 22(3):201-206.
[17] SENGUPTA S,WILLIAM HENRY R. Regulation of the retinoblastoma-E2F pathway by the ubiquitin-proteasome system[J].Biochim Biophys Acta,2015,1849(10):1289-1297.