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| Efficacy of Apatinib Mesylate Tablets in the Treatment of Advanced Gastric Cancer |
| LIU Fu, MA Pei, WEI Hai |
| The First Department of Gastrointestinal Surgery, Nanyang First People's Hospital, Nanyang, Henan 473000 |
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Abstract 【Objective】To observe the efficacy of apatinib mesylate tablets in the treatment of advanced gastric cancer and to provide reference for clinical treatment. 【Methods】A total of 70 patients with advanced gastric cancer after first-line chemotherapy (FOLFOX regimen) were randomly divided into two groups. The control group was treated with tigio and the observation group was treated with apatinib mesylate tablets. The clinical efficacy of the two groups after treatment was analyzed. 【Results】In the observation group, there was 1 case of complete remission and 15 cases of partial remission. The objective remission rate was 45.71%. There were 0 cases of complete remission in the control group and 14 cases of partial remission. The objective remission rate was 40.00% (14/35). There was no significant difference in the objective remission rate between the two groups (P>0.05). There was no significant difference in the levels of interferon-gamma (INF- γ), IL-4 (IL-4), serum sugar chain antigen 19- 9 (CA19-9), and sugar chain antigen 72 -4 (CA72-4) between the two groups before treatment (P>0.05). After treatment, the levels of INF- γ and IL-4, CA19-9, CA72-4 in the two groups were higher than those before treatment, and the levels of INF- γ and IL-4, CA19-9, and CA72-4 in the observation group were better than those in the control group after treatment (P<0.05). The incidence of hypertension (22.86%) was higher in the observation group than in t the control group (5.71%), the incidence of diarrhea (11.43%) was lower than that in the control group (31.43%), and the incidence of nausea and vomiting (8.57%), hand and foot syndrome (2.86%), and neutropenia (0.00%) were lower than those of the control group (11.43%, 5.71%, 5.71%, respectively). The difference was statistically significant (P<0.05). 【Conclusion】Apatinib mesylate tablets and tigio tablets have similar efficacy in the treatment of advanced gastric cancer. Apatinib mesylate tablets have more obvious improvement on related cytokines, but attention should be paid to the occurrence of hypertension.
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Received: 15 October 2019
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2021, Vol. 38 
