银杏二萜内酯葡胺注射液联合阿替普酶静脉溶栓治疗高龄急性缺血性脑卒中患者的临床疗效

doi:10.3969/j.issn.1671-7171.2021.06.005

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1139 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the clinical efficacy of Ginkgo diterpenoid lactone meglumine injection (DGMI) combined with alteplase (rt-PA) intravenous thrombolysis in the treatment of elderly patients with acute ischemic stroke (AIS). 【Methods】 From January 2018 to August 2020, 86 elderly patients with AIS in Shanghai Yangpu District Central Hospital were selected as the research objects, and the observation group and the control group were randomly divided into two groups, 43 cases in each group. The control group was treated with rt-PA intravenous thrombolysis, and the observation group was treated with DGMI on the basis of the control group for 2 weeks. The clinical efficacy, neurological function, activities of daily living, serum levels of amyloid A (SAA), lipoprotein associated phospholipase A2 (Lp-PLA2) and hemorheological parameters were compared between the two groups before and after treatment. 【Results】The total effective rate of the observation group was 93.02% (40/43), significantly higher than 74.42% (32/43) of the control group, the difference was statistically significant(χ²=5.460,P=0.019). After treatment, the clinical neurological deficit score (NDS), serum SAA, Lp-PLA2 levels, high shear and low shear whole blood viscosity and plasma viscosity of the two groups were significantly lower than those of the same group before treatment (mean P<0.05), and the observation group was significantly lower than that of the control group (mean P<0.05); After treatment, ADL of the two groups was significantly higher than that of the same group before treatment (mean P<0.05), and the observation group was significantly higher than that of the control group (P<0.05). 【Conclusion】 DGMI combined with rt-PA intravenous thrombolysis in the treatment of elderly patients with AIS has significant curative effect, can effectively improve the hemorheology of patients, significantly reduce the serum SAA, Lp-PLA2 levels, reduce the degree of neurological deficit, and improve the ability of daily living, it is worthy of clinical application.

Key words： Brain Ischemia Stroke Acute Disease Aged, 80 and over Tissue Plasminogen Activator/TU Diterpenes/TU

Received: 25 October 2020

PACS:

R743.31

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XU Hui
	ZHANG Xiao-guang
	YUE Yun-hua
	et al

Cite this article:

XU Hui,ZHANG Xiao-guang,YUE Yun-hua, et al. Clinical Efficacy of Ginkgo Diterpenoid Lactone Meglumine Injection Combined with Alteplase Intravenous Thrombolysis in the Treatment of Elderly Patients with Acute Ischemic Stroke[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(6): 820-823.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.06.005 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I6/820

[1] 李洪杰,杜昌儒,邓博师,等.高龄急性缺血性脑卒中患者静脉溶栓后出血性转化的危险因素[J].中华老年多器官疾病杂志,2020,19(10):740-744.
[2] 胡明,王宏保,谢富友,等.阿替普酶静脉溶栓联合丁苯酞注射液治疗急性脑卒中的临床疗效[J].安徽医学,2020,41(11):108-112.
[3] 张艳,陈莹,樊榕,等.银杏二萜内酯葡胺注射液联合rt-PA静脉溶栓治疗急性缺血性脑卒中患者的临床观察[J].实用药物与临床,2020,23(11):1015-1018.
[4] SCHWEIZER J, BUSTAMANTE A, LAPIERRE-FÉTAUD V, et al.SAA (Serum Amyloid A):a novel predictor of stroke-associated infections[J].Stroke,2020,51(12):3523-3530.
[5] 冉桥生,张立群,刘飞,等.Lp-PLA2,NLR,RDW对AIS的诊断价值研究[J].国际检验医学杂志, 2020,41(17):15-23.
[6] 中华医学会神经病学分会.中国急性缺血性脑卒中诊治指南[J].中华神经科杂志,2018,51(9):666-682.
[7] 国家中医药管理局脑病急症协作组.中风病诊断与疗效评定标准(试行)[M].北京中医药大学学报,1996,19(1):55-56.
[8] 巫嘉陵,王纪佐,王世民,等.脑卒中患者临床神经功能缺损程度评分的信度与效度[J].中华神经科杂志,2009,42(2):75-78.
[9] 陈善佳,周小炫,方云华,等.日常生活活动能力量表在脑卒中康复临床使用情况的调查[J].中国康复医学杂志,2014,29(11):1044-1049.
[10] DIENER H C, HANKEY G J.Primary and secondary prevention of ischemic stroke and cerebral hemorrhage:JACC focus seminar[J].J Am Coll Cardiol,2020,75(15):1804-1818.
[11] RINGLEB P,BENDSZUS M,BLUHMKI E,et al.Extending the time window for intravenous thrombolysis in acute ischemic stroke using magnetic resonance imaging-based patient selection[J].Int J Stroke,2019,14(5):483-490.
[12] WIJERATHNE H,WITEK M A,BAIRD A E,et al.Liquid biopsy markers for stroke diagnosis[J].Expert Rev Mol Diagn,2020,20(8):771-788.
[13] 郑志刚,李万里.脑苷肌肽注射液联合rt-PA静脉溶栓对急性缺血性脑卒中患者NIHSS评分及血清IGF-1水平的影响[J].黑龙江医药科学,2019,42(4):193-194.
[14] 王中雨.中西医结合治疗脑卒中风痰瘀阻型临床观察[J].实用中医药杂志,2019, 35(2):188-189.
[15] 王青松,陶艳丽,丁志刚,等.银杏二萜内酯葡胺联合单唾液酸四己糖神经节苷脂对急性期脑梗死神经功能的影响[J].中国实用神经疾病杂志,2020,23(8):27-32.
[16] 彭彩亮,蒋宁,陈晓朋,等.银杏二萜内酯葡胺注射液对缺血性脑卒中患者血清Sestrin2,同型半胱胺酸,D-二聚体,超敏C反应蛋白水平影响[J].临床军医杂志, 2020,48(4):101-105.
[17] 魏婉,缪卫琴,蒋敏海.血清淀粉样蛋白A、触珠蛋白水平与急性脑梗死患者预后的相关性[J].浙江医学, 2018,40(6):631-634.
[18] 杨春生,刘玉,孟玉玫,等.血清Hcy, sdLDL-C, Lp-PLA2水平与急性脑梗死严重程度及阿替普酶溶栓效果的关系[J].标记免疫分析与临床, 2020,27(4):618-621.