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| Relationship between LKB1 Gene Expression and Survival Rate of Gastric Cancer |
| KANG Ming-xiang |
| Department of Gastroenterology, Luxian people's Hospital, Luzhou, Sichuan 646100 |
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Abstract 【Objective】To investigate the relationship between liver kinase B1 (LKB1) gene expression and the survival rate of gastric cancer. 【Methods】From June 2012 to June 2013, 46 cases of gastric cancer tissue samples were collected and the clinical and pathological data were analyzed retrospectively. The expression of LKB1 protein in gastric cancer tissue was detected by immunohistochemistry, and the relationship between LKB1 gene expression and clinicopathological parameters with survival rate was also analyzed. 【Results】The positive expression rate of LKB1 protein in gastric cancer was 19.57% (9/46), significantly lower than that in normal adjacent tissues (89.13%, P<0.05). There was no significant difference in age, sex, lymph node metastasis and histopathological classification (P>0.05). There was significant difference in tumor size, TNM stage, and serosal infiltration (P<0.05). The average survival time of LKB1 low expression group was 43.9 months and that of high expression group was 52.6 months. The 5-year survival rate of LKB1 low expression group was significantly lower than that of LKB1 high expression group (P<0.05) . 【Conclusion】LKB1 gene plays an important role in inhibiting the occurrence and development of gastric cancer, improving prognosis, and improving survival rate of patients. Therefore, the mechanism of tumor suppressor gene LKB1 in the diagnosis, treatment, and prognosis of gastric cancer deserves attention, which can provide a new breakthrough for the treatment of gastric cancer.
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Received: 15 October 2019
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[1] 左婷婷, 郑荣寿, 曾红梅,等. 中国胃癌流行病学现状[J].中国肿瘤临床, 2017, 44(1):52-58.
[2] 苗儒林,李子禹,季加孚.从中国胃肠肿瘤外科联盟相关数据分析我国早期胃癌诊治现状和发展趋势[J].中国实用外科杂志,2019,39(5):419-423.
[3] 申洪. 免疫组织化学染色定量方法研究(Ⅲ)[J].中国组织化学与细胞化学杂志,1995(1):89-92.
[4] 王胤奎, 李子禹, 陕飞,等. 我国早期胃癌的诊治现状——来自中国胃肠肿瘤外科联盟数据的启示[J].中华胃肠外科杂志, 2018, 21(2):168-174.
[5] Xie Y, Zhi X, Su H, et al. A Novel electrochemical microfluidic chip combined with multiple biomarkers for early diagnosis of gastric cancer[J].Nanoscale Res Lett,2015, 10(1):477-478.
[6] Jiang C, Chen X, Alattar M, et al. MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer[J].Cancer Gene Ther,2015, 22(6):291-301.
[7] Sun J, Ling B, Xu X, et al. Decreased Expression of Tumor-suppressor Gene LKB1 Correlates with Poor Prognosis in Human Gastric Cancer[J].Anticancer Res,2016, 36(3):869-875.
[8] Mi RC, Chang HA, Yoo NJ, et al. Frameshift Mutations of CAB39L, an Activator of LKB1 Tumor Suppressor, in Gastric and Colorectal Cancers[J].Pathol Oncol Res,2016, 22(1):225-226.
[9] 周新刚, 陈佳敏, 高海丽,等. LKB1和PTEN在肝细胞癌中的表达及临床意义[J].中华普通外科杂志, 2018, 33(5):420-424. |
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2021, Vol. 38 
