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| Expression and Clinicopathological Significance of Leptin and N-Cadherin Expression in Patients with Colorectal Cancer |
| LI Mei-lin, LIU Hong-bin, ZHANG Hai-ming, et al |
| Changsha City Central Hospital Oncology Department Hunan Province Changsha 410006 |
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Abstract 【Objective】To investigate the relationship of leptin and N-Cadherin protein expression with clinicopathological features in colorectal cancer. 【Methods】The expression of leptin and N-Cadherin protein was evaluated by immunohistochemistry in 120 cases of colorectal cancer. The relationship between the staining pattern and clinicopathogical features was analyzed.【Results】The positive rates of leptin and N-Cadherin protein in colorectal cancer were 75.8% (91/120) and 68.3%(82/120), respectively. The expression intensity of leptin and N-Cadherin protein was related to invasive depth, TNM stages, lymph node metastasis and tumor differentiation of colorectal cancer. The difference was statistically significant (P<0.05). In colorectal cancer tissues, the leptin expression was positively correlated with N-Cadherin expression; and the difference was statistically significant (P<0.001).【Conclusion】Leptin and N-Cadherin may play an important role in the occurrence and development of colorectal cancer. The detection of leptin and N-Cadherin may be helpful for the evaluation of prognosis and treatment for colorectal cancer patients.
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Received: 04 December 2020
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2021, Vol. 38 
