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| Effect of Laparoscopic Assisted AlPPS in Primary Liver Cancer and its Influence on Serum miR-145, miR-143 and Immune indexes |
| ZHAO Jing-xuan, SUN Xin-ru, ZHAO Na |
| Yangling Demonstration Zone Hospital, Shaanxi 712100 |
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Abstract 【Objective】To investigate the effect of laparoscopic assisted ALPPS(associating liver partition and portal vein ligation for staged hepatectomy)one-stage surgery in the treatment of primary liver cancer (PLC) and its influence on the levels of microrna-145 (miR-145), miR-143 and immune indexes. 【Methods】 A total of 63 PLC patients from April 2017 to may 2020 in our hospital were selected and divided into observation group (laparoscopic assisted AlPPS,n=32) and control group (open AlPPS,n=31). The operation and complications of the two groups were compared. The serum humoral immune function indexes (immunoglobulin M (IgM), immunoglobulin A (IGA), immunoglobulin G (IgG)) and liver function indexes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBiL) were compared between the two groups before and 3 days after operation. The levels of miR-145 and miR-143 were compared between the two groups before operation, 3 days and 1 week after operation. 【Results】The postoperative exhaust time, hospital stay and intraoperative blood loss of the observation group were shorter than those of the control group, and the difference was statistically significant (P<0.05). The incidence of postoperative complications in the observation group was 12.50% (4/32), which was lower than 29.03 (9/31) in the control group, but the difference was not statistically significant (χ2=2.628, P=0.105>0.05). The levels of serum IgM, IgA and IgG in the two groups were lower than those before operation, but the observation group was higher than the control group, the difference was statistically significant (P<0.05); the serum ALT, AST, TBiL levels were higher than those before operation, but the observation group was lower than the control group, the difference was statistically significant (P<0.05). The serum levels of miR-145 and miR-143 in the observation group were lower than those in the control group 3 days and 1 week after operation, and the difference was statistically significant (P<0.05). 【Conclusion】Laparoscopic assisted AlPPS one-stage surgery for PLC patients has the advantages of small trauma, less bleeding and rapid postoperative recovery. It can protect liver function, reduce immune function damage, and reduce the expression of miR-145 and miR-143 in serum.
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Received: 14 October 2020
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2020, Vol. 37 
