Abstract【Objective】 This report aims to study the relationship of homocysteine (Hcy), serum amyloid protein A (SAA) and lipoprotein associated phospholipase A2 (Lp-PLA2) with early diabetic foot and to assess possible diagnostic value for early diabetic foot. 【Methods】 We collected 252 patients with Wagner grade 1 and 2 diabetic foot as the observation group and 175 type 2 diabetes mellitus patients without complications as the control group. The serum levels of Hcy, SAA and Lp-PLA2 were compared between the two groups and their diagnostic value in early diabetic foot was evaluated. 【Results】 After statistical analysis, we found that differences of Hcy ,SAA and Lp-PLA2 levels between the two groups were bio-statistically significant (P<0.05). Hcy, SAA and Lp-PLA2 were the risk factors of early diabetic foot (β value was 0.448, 0.206 and 0.044,respectively.) and they all showed statistical significance (P<0.001). The ROC curve showed that area under curve (AUC) of Hcy, SAA and Lp-PLA was 0.918, 0.892 and 0.967, respectively. The combination AUC of three parameters was 0.99.【Conclusion】 Form this study we know that the levels of Hcy,SAA and Lp-PLA2 in patients with early diabetic foot are higher than those of T2DM patients without diabetic foot complication. Hcy, Lp-PLA2 and SAA are the risk factors of early diabetic foot in T2DM, and combined detection is of great significance in the early diagnosis of diabetic foot.
XIAO Xi,CHEN Jian. Diagnostic Value of Homocysteine, Serum Amyloid A, Lipoprotein Associated Phospholipase A2 for Early Diabetic Foot[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(10): 1520-1522.
2020, Vol. 37 
