幼年皮肌炎50例临床特征及其诊治分析

doi:10.3969/j.issn.1671-7171.2020.10.012

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Abstract 【Objective】 To study the clinical characteristics, therapeutic effect and prognosis of juvenile dermatomyositis. 【Methods】 Fifty cases of juvenile dermatomyositis hospitalized in Hunan children's Hospital from July 2011 to January 2020 were analyzed retrospectively. The onset, clinical characteristics, laboratory examination, auxiliary examination, treatment, follow-up and prognosis were analyzed. 【Results】 In 50 juvenile dermatomyositis, the ratio of male to female patients was 1.08∶1, with an average age of 8.5±4.5 years. Of which, 11 children had a history of upper respiratory tract infection before the onset of the disease. . There were 2 cases who had typical skin lesions without myositis symptoms. They both had weakened muscle strength but normal muscle tension. The most common visceral damage was interstitial pneumonia. All the children had typical skin lesions, but no muscle atrophy and calcinosis. No malignant tumor was found. All 50 cases were treated with glucocorticoid; and 9 out of 50 cases received glucocorticoid combined with methotrexate. The therapeutic effect and prognosis were good. 【Conclusion】 Juvenile dermatomyositis is a rare disease in children, which is characterized by skin damage and muscle weakness. Muscle enzyme and electromyogram are very useful for the diagnosis of juvenile dermatomyositis. Glucocorticoid therapy is effective, if necessary, combined with immunosuppressant.

Key words： Dermatomyositis/DI Dermatomyositis/TH

Received: 18 June 2020

PACS:

R725.932.6

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.10.012 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I10/1480

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