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| Clinical Significance of Serum Tumor Marker Detection in Lymphoma Patients |
| PAN Ming, YANG Zhen, HU An-qun |
| Anqing Municipal Hospital Laboratory Department,Anqing 246000, Anhui |
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Abstract 【Objective】 To investigate the application of serum tumor markers combined with bone marrow morphometry in patients with lymphoma. 【Methods】 A total of 52 patients with lymphoma in our hospital were selected as the observation group (including 22 cases with tumor infiltration and 30 cases with non-infiltration). At the same time, 52 healthy volunteers were selected as the control group. The levels of serum ferritin (SF), carcinoembryonic antigen 15-3 (CA15-3), carcinoembryonic antigen 125 (CA125), carcinoembryonic antigen (CEA), clinical data and cell morphology were compared between the two groups. 【Results】 (1) The levels of SF, CA15-3, CA125 and CEA in the observation group were higher than those in the control group (P<0.05). The levels of SF, CA15-3, CA125 and CEA in patients with tumor infiltration were higher than those with non-invasive infiltration (P<0.05). (2) Serum SF, CA15-3, CA125, CEA had no correlation with age, gender, WBC, HGB, PLT, lymphocyte proportion (P>0.05), while serum CA15-3, CA125 had correlation with infant lymphocyte proportion (P<0.05), serum SF, CA15-3, CA125, CEA had correlation with lymphoma B symptoms (P<0.05), serum SF and CA15-3 had correlation with lymphoma stage (P<0.05), serum SF, CA15- 3 and CA125 were correlated with international prognostic index (IPI) (P<0.05). 【Conclusion】 Serum tumor markers combined with bone marrow morphometry can be helpful to the diagnosis, staging, and prognosis of lymphoma, and provide a reliable reference for the diagnosis of bone marrow infiltration. It has important clinical significance.
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Received: 02 July 2019
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[1] 汪海涛,杨波,蔡力力,等.30例老年非霍奇金淋巴瘤的临床病理学特征、疗效及预后分析[J].中国实验血液学杂志,2013,21(6):1464-1470.
[2] 任羽,贺爱军.血清肿瘤标志物联合骨髓形态检测在淋巴瘤患者中的临床意义[J].中国肿瘤临床与康复,2017,24(7):803-806.
[3] 庹有林.乳腺超声光散射成像联合血清 CA15-3,CEA 检测在乳腺肿瘤中的诊断价值[J].中国医药导报,2017,14(26):90-93.
[4] Saldova R, Struwe, WB, et al. Exploring the glycosylation of serum CAl25[J].Int J Mol Sci,2013, 4(8): 11565-15636.
[5] 舒文秀,乐静,万斌,等.血清肿瘤标志物在非霍奇金淋巴瘤诊断及预后判断中的临床价值[J].临床血液学杂志,2011,24(2):160.
[6] 黄红,毛琴,全胜麟,等.4种血清肿瘤标志物在原发性胃淋巴瘤的临床应用研究[J].重庆医学,2013,42(26):3117-3119.
[7] 杨方方,向琪,王顺清.恶性淋巴瘤血清CA125的表达及临床意义[J].中国热带医学,2014,14(11):1314-1316, 1339.
[8] 刘兰凤,田斌,刘海燕,等.肿瘤标志物CEA、AFP、CA19-9和CA72-4的检测在消化系统恶性肿瘤中的应用[J].国际检验医学杂志,2017,38(5):596-597.
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2020, Vol. 37 
