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| Clinical Effects of Clopidogrel Combined with Aspirin in Patients with Type 2 Diabetes Complicated with Acute Cerebral Infarction |
| WANG Ke, WANG Yang |
| Wuhan Red Cross Hospital, Hubei Wuhan 430015 |
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Abstract 【Objective】To investigate the clinical effect of clopidogrel combined with aspirin in patients of type 2 diabetes mellitus (T2DM) with acute cerebral infarction. 【Methods】Retrospectively, a total of 82 patients with T2DM complicated with acute cerebral infarction from August 2016 to October 2018 in our hospital were divided into the observation group and the control group according to the treatment methods. Patients in the control group received conventional aspirin, while those in the observation group received clopidogrel and aspirin. The clinical effects of the two groups after treatment were analyzed. 【Results】The fasting blood glucose (FPG), postprandial 2h blood glucose (2hPG), glycosylated hemoglobin (HbA1c), vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), angiotensin-ii (Ang-Ⅱ), mean platelet volume (MPV), large platelet ratio (P-LCR) level, carotid intima-media thickness (IMT), plaque number and plaque area between the two groups were not statistically significant (P>0.05). After treatment, the levels of FPG,2hPG, HbAlc, MMP-9,Ang-II,MPV,P-LCR,IMT,plaque number and area in the observation were lower than those in the control group (P<0.05), while VEGF level in the observation group was higher than that in the control group (P<0.05). Before treatment, there was no significant difference in the scores of neurological impairment (NIHSS) between the two groups (P>0.05), however, the scores of NIHSS in the observation group at 6 and 12 days after treatment were significantly lower than those in the control group (P<0.05). 【Conclusion】Clopidogrel combined with aspirin in the treatment of T2DM with acute cerebral infarction can effectively improve the status of blood glucose and nerve function of patients, which is worthy of clinical application.
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Received: 21 February 2019
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2020, Vol. 37 
