PDGF、HMGB1在子宫内膜异位症患者血清中的表达及其临床意义

doi:10.3969/j.issn.1671-7171.2020.03.027

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Abstract 【Objective】To investigate the expression of platelet-derived growth factor (PDGF) and high mobility group protein B1 (HMGB1) in the serum of patients with endometriosis (EMs) and its clinical significance.【Methods】From March 2016 to March 2019, 80 EMS patients in our hospital were selected as the observation group and 68 healthy women were included as the control group. The expression of PDGF and HMGB1 in serum of the two groups were detected and compared, and the correlation between PDGF and HMGB1 and clinical stage, lymph node metastasis and deep infiltration of EMS patients were analyzed. The influencing factors of EMs were analyzed by logistic regression.【Results】The levels of PDGF and HMGB1 in the observation group were significantly higher than those in the control group (P<0.05); the serum levels of PDGF and HMGB1 in EMs patients with clinical stage Ⅲ~Ⅳ, lymph node metastasis and deep infiltrating focus were higher than those in patients with clinical stageⅠ~Ⅱ, no lymph node metastasis and no deep infiltrating focus (P<0.05);Logistic regression analysis showed that serum PDGF and HMGB1 were risk factors of EMs (P<0.05); the results of Spearman correlation analysis showed that the expression of PDGF and HMGB1 in serum was positively correlated with stage Ⅲ~Ⅳ, lymph node metastasis and deep infiltrating lesions in EMs patients (all P<0.05).【Conclusion】The serum PDGF and HMGB1 of patients with EMs are abnormally high expression, which are closely related to stage Ⅲ~Ⅳ, lymph node metastasis and deep infiltrative lesions. It can provide basis for disease monitoring and prognosis evaluation, and provide new targets for follow-up treatment.

Key words： Endometriosis Platelet Derived Grow Factor

Received: 20 May 2018

PACS:

R711.71

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.03.027 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I3/412

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