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| Predictive Value of Monocyte/High-density Lipoprotein Ratio for Cardiovascular Events in Patients with Chronic Kidney Disease |
| YANG Xi, HUA Xue-lian |
| Clinical Laboratory, Taikang Xianlin Drum Tower Hospital, Nanjing, Jiangsu, 210046 |
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Abstract 【Objective】To investigate the relationship of monocyte/high-density lipoprotein ratio (MHR) with chronic kidney disease (CKD) stage and predictive value of cardiovascular events in patients with CKD. 【Methods】A total of 180 patients with non-hemodialysis CKD (stage 3 to 5) in our hospital were collected for the study. According to the level of glomerular rate filtration (GFR), patients were divided into group A (CKD stage 3, n=65 cases), group B (CKD stage 4, n=55 cases) and group C (CKD stage 5, n=60 cases). They further were divided into the cardiovascular event group (n=75 cases) and non-cardiovascular event group (n=105 cases) depending on cardiovascular events occurred within 6 months of follow-up. There were 40 healthy volunteers enrolled in the control group. Blood routine, high-density lipoprotein (HDL), creatinine, urea nitrogen, NT-proBNP, GFR and MHR were recorded and compared among groups. The relationship of MHR with GFR and NT-proBNP was analyzed by Spearman correlation analysis. The predictive value of MHR and NT-proBNP on cardiovascular events in patients with CKD was analyzed by drawing the ROC curve. 【Results】The levels of MHR and NT-proBNP increased gradually with the increase of CKD stages, showing that the level of group C> group B> group A> the control group (P<0.05).The levels of MHR and NT-proBNP in patients with cardiovascular events were significantly higher than those in non-cardiovascular events (P<0.05). In patients with CKD, MHR was negatively correlated with GFR (P<0.01), while MHR was positively correlated with NT-proBNP (P<0.01).The area under the ROC curve for diagnosis of cardiovascular events by MHR and NT-proBNP in CDK patients were 0.958 and 0.932, respectively. The diagnostic sensitivities were 92% and 86.7%, respectively, and the specificity were 92.6% and 89.6%, respectively. 【Conclusion】There is a close relationship between the occurrence of cardiovascular events and inflammatory state in CKD patients. MHR is superior to traditional indicators in predicting the occurrence of cardiovascular events in CKD patients.
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Received: 27 November 2018
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2019, Vol. 36 
