Abstract【Objective】To investigate the relationship of monocyte/high-density lipoprotein ratio (MHR) with chronic kidney disease (CKD) stage and predictive value of cardiovascular events in patients with CKD. 【Methods】A total of 180 patients with non-hemodialysis CKD (stage 3 to 5) in our hospital were collected for the study. According to the level of glomerular rate filtration (GFR), patients were divided into group A (CKD stage 3, n=65 cases), group B (CKD stage 4, n=55 cases) and group C (CKD stage 5, n=60 cases). They further were divided into the cardiovascular event group (n=75 cases) and non-cardiovascular event group (n=105 cases) depending on cardiovascular events occurred within 6 months of follow-up. There were 40 healthy volunteers enrolled in the control group. Blood routine, high-density lipoprotein (HDL), creatinine, urea nitrogen, NT-proBNP, GFR and MHR were recorded and compared among groups. The relationship of MHR with GFR and NT-proBNP was analyzed by Spearman correlation analysis. The predictive value of MHR and NT-proBNP on cardiovascular events in patients with CKD was analyzed by drawing the ROC curve. 【Results】The levels of MHR and NT-proBNP increased gradually with the increase of CKD stages, showing that the level of group C> group B> group A> the control group (P<0.05).The levels of MHR and NT-proBNP in patients with cardiovascular events were significantly higher than those in non-cardiovascular events (P<0.05). In patients with CKD, MHR was negatively correlated with GFR (P<0.01), while MHR was positively correlated with NT-proBNP (P<0.01).The area under the ROC curve for diagnosis of cardiovascular events by MHR and NT-proBNP in CDK patients were 0.958 and 0.932, respectively. The diagnostic sensitivities were 92% and 86.7%, respectively, and the specificity were 92.6% and 89.6%, respectively. 【Conclusion】There is a close relationship between the occurrence of cardiovascular events and inflammatory state in CKD patients. MHR is superior to traditional indicators in predicting the occurrence of cardiovascular events in CKD patients.
YANG Xi,HUA Xue-lian. Predictive Value of Monocyte/High-density Lipoprotein Ratio for Cardiovascular Events in Patients with Chronic Kidney Disease[J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(11): 2157-2159.
[1] 张志宏,张丽华,郑春霞,等.循环半乳糖凝集素3水平预测慢性肾脏病患者心血管事件风险的价值[J].肾脏病与透析肾移植杂志,2016,25(2):101-106,158. [2] 苏晓燕,丁苏,邓惠钊,等.缺血修饰白蛋白对慢性肾脏病患者心血管事件的预测价值[J].中国血液净化,2016,15(8):392-395. [3] 王林,刘先双,刘亚楠,等.慢性肾脏病患者心血管事件相关预测因子[J].医学综述,2016,22(2):248-251. [4] Ganjali S, Gotto AM Jr, Ruscica M,et al. Monocyte-to-HDL-cholesterol ratio as a prognostic marker in cardiovascular diseases[J].J Cell Physiol,2018,233(12):9237-9246. [5] 美国NKF-K/DOQI工作组.慢性肾脏病及透析的临床实践指南[M].北京:人民卫生出版社,2003:1-7. [6] 宋昊岚,杨婷婷,李贵星.N末端脑利钠肽前体(NT-proBNP)在评估慢性肾脏疾病患者心功能中的价值[J].四川大学学报(医学版),2017,48(4):561-565. [7] 杨理惠. 冠心病合并糖尿病患者单核细胞/高密度脂蛋白比率与其冠状动脉狭窄程度的关系[D].郑州大学,2018. [8] Kanbay M, Solak Y, Unal HU,et al.Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease[J].Int Urol Nephrol,2014,46(8):1619-1625.
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(9): 1820-1821.
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