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| Analysis of the Relationship between One-year Vaginal Microecological Treatment and HPV Outcome in Patients with High-grade Squamous Intraepithelial Lesions |
| WANG Juan |
| Department of obstetrics and gynecology, changzhou jintan district people's hospital, Changzhou Jiangsu 213200 |
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Abstract 【Objective】To investigate the relationship between the vaginal microecological one-year therapy and the outcome of HPV in patients with high grade squamous intraepithelial lesions (HSIL). 【Methods】The clinical data of 96 cases of HSIL treated in our hospital from January 2013 to September 2017 were analyzed retrospectively. According to whether HPV turned negative in one year after treatment, they were divided into HPV persistent infection group (50 cases) and HPV turned negative group (46 cases). One year after treatment, the basic situation, the density of vaginal flora, the diversity of vaginal flora and the nature of vaginal flora were compared between the two groups. 【Results】There was no significant difference in age and chronic diseases between the two groups (P>0.05); the surface squamous cells and gynecological diseases in the HPV persistent infection group were significantly higher than those in the HPV transvaginal group (P<0.05); the abnormal rates of vaginal flora density, flora diversity and flora property in the HPV persistent infection group were significantly higher than those in the HPV transvaginal group (P<0.05). Multivariate logistic regression analysis showed that the diversity of vaginal flora and the nature of vaginal flora were independent risk factors for HPV outcome (P<0.05). 【Conclusion】The balance of vagina microecology is the key to the prognosis of HPV. In order to control the occurrence and development of HSIL and reduce the risk of cervical cancer, targeted treatment can be carried out according to the diversity of vagina flora and the number of dominant bacteria.
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Received: 14 October 2018
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2019, Vol. 36 
