PPARγ和P16在宫颈癌和宫颈鳞状上皮内病变患者宫颈组织中的表达及其与HPV感染的关系

doi:10.3969/j.issn.1671-7171.2019.11.012

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the expression of peroxisome proliferator activated receptor gamma (PPARγ) and P16 protein in cervical squamous cell carcinoma (SCC) and cervical intraepithelial lesion (SIL), and possible correlation with HPV infection. 【Methods】Expressions of PARγ and P16 in 17 cases of normal cervical epithelium (NCE),52 cases of SIL and 39 cases of SCC were measured by immunohistochemical MAXVisionTM method.HPV infection was detected by reverse dot blot hybridization method. The correlation between the expression of PPARγ and P16 with HPV infection was analyzed. 【Results】The positive expression rate of PPARγ and P16 from NCE to SIL and SCC showed a gradual increasing trend; the differences among groups were statistically significant (P<0.05). The infection rate of HPV in NCE,SIL and SCC was 29.41% (5/17),76.92% (40/52) and 97.44% (38/39), respectively, which also showed a gradual increasing trend. The difference between groups was statistically significant (P<0.05). The expressions of PPARγ and P16 were positively correlated with HPV infection (P<0.05). 【Conclusion】The expressions of PPARγ and P16 are highly expressed in cervical SCC tissues. PPARγ and P16 expressions are positively correlated with HPV infection, which play an important role in the development of cervical carcinoma.

Key words： Uterine Cervical Neoplasms/PP Peroxisome Proliferator-Activated Receptors Papillomaviridae

Received: 27 November 2018

PACS:

R737.33

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2019.11.012 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2019/V36/I11/2118

[1] 马莉,丛笑,卞美璐,等.高危型HPV分型检测作为子宫颈癌及其癌前病变初筛手段的探讨[J].中华妇产科杂志,2015,50(4): 246-252.
[2] Xiao W,Bian M,Ma L,et al.Immunochemical analysis of human papillomavirus L1 capsid protein in liquid-based cytology samples from cervical lesions[J].Acta Cytol,2016,54(5):661 -667.
[3] 潘琼慧,黄凌霄,陈育梅,. P16INK4A、L1 壳蛋白联合检测在宫颈鳞状上皮内病变中的应用研究进展[J].实用医学杂志,2015,31(2):324-326.
[4] 高宝莲,钱萍,马祯一,等. 宫颈鳞状上皮病变中人乳头瘤病毒L1 蛋白与 P16、Ki-67 的表达及意义[J].中国妇幼保健,2015,30(7 ): 1109-1111.
[5] 王丽凤,韩蓉晖,李丽,等. 高危型人乳头瘤病毒感染的子宫颈鳞状上皮组织中 p16INK4α 蛋白表达及其意义[J].肿瘤研究与临床,2016,28 (11): 757-760.
[6] 王璐,王晨阳,王武亮,等.高危型人乳头瘤病毒 E_6 /E_7 mR-NA 检测对宫颈高度鳞状上皮内病变诊断及随访价值研究[J].中国实用妇科与产科杂志,2016(6):580-582.
[7] 李玮,吕杰强,鲁意. 人乳头状瘤病毒混合感染对高度鳞状上皮内病变和宫颈癌的风险研究[J].中华实验和临床病毒学杂志,2015,29(1):41-43.
[8] 王娟,李燕,赵骏达,等. 人乳头状瘤病毒 L1 壳蛋白和人端粒酶RNA 基因联合检测在宫颈癌筛查中的意义[J].中国医药导报,2015,12(17):60-63.
[9] 李芳,张祥宏,张飞燕.子宫颈鳞状细胞癌中过氧化物酶体增殖物激活受体γ、维甲酸类X受体α及环氧合酶2的表达及其意义[J].肿瘤研究与临床,2017,(10):658-662.
[10] 苏光,唐振利,张凡,等. HPVL1 蛋白和 HMGA1 在子宫颈病变中的表达及临床意义[J].中国妇产科临床杂志,2016,17(4):319-322.
[11] 刘爱民,陈益萍,杨若玲.宫颈脱落细胞中Ki67、P16阳性表达的临床意义[J].医学临床研究,2012,29(9):1678-1680.
[12] 姚文娟、王凤琴、于婧,等.IL-6和STAT3在宫颈癌组织中的表达及其与HPV的相关性[J].医学临床研究,2019,36(4):727-729.