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| Clinical Observation of Different Doses of Intranasal Dexmedetomidine to Prevent Postoperative Shivering after Hepatectomy |
| LUO Feng, CHEN Wen-yan, TANG Yi-xun, et al |
| The People's Hospital of Hunan Province,410005,Changsha,Hunan |
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Abstract 【Objective】 To investigate the effects of different doses of dexmedetomidine(Dex) nasal drops in the prevention of postoperative chills after hepatectomy.【Methods】 A total of 120 patients with laparoscopic lobectomy were randomly divided into four groups with 30 patients in each group. Patients in the control group (group C) received normal saline before tracheal catheter extraction, while patients in group D1, D2 and D3 received Dex 0.5μg/kg、1μg/kg、2μg/kg, respectively.The incidence of nasopharyngeal temperature, grade of shivering, waking time, extubation time and other adverse reactions were recorded. 【Results】 There was no significant difference in the incidence and severity of postoperative shivering between group D1 and group C (P＞ 0.05). Compared to group C, the incidence and severity of postoperative shivering were significantly lower in group D2 and group D3 (P ＜0.05). However, there was no significant difference between group D2 and D3 (P＞0.05). There was no significant difference in waking time, extubation time and sedation incidence among group C, D1 and D2 (P＞0.05). The recovery time, extubation time and sedation rate of patients in group D3 were higher than those in group C (P＜0.05). There was no significant difference in the incidence of nausea, vomiting and respiratory depression in all four groups (P＞0.05). 【Conclusion】 Prophylactic intranasal administration of 1μg/kg of Dex in patients with hepatic lobectomy can effectively prevent postoperative shivering.
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Received: 10 September 2018
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(6): 1224-1227. |
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2018, Vol. 35 
