PTEN、COX2蛋白在复发转移性大肠癌患者组织中的表达及临床意义

doi:10.3969/j.issn.1671-7171.2018.12.007

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Abstract 【Objective】 To study the expression and clinical significance of phosphatase and tensin homolog deleted on chromosome ten (PTEN) and Cyclic oxidase-2 (COX2) protein in patients with recurrent metastatic colorectal cancer. 【Methods】 From February 2016 to February 2017, 50 patients with recurrent and metastatic colorectal cancer (recurrence and metastasis group) and 50 patients with recurrent and unmetastatic colorectal cancer treated in our hospital from February 2016 to February 2017 were selected as simple recurrence group. Fifty patients with primary colorectal cancer who were treated in our hospital at the same time were selected as the primary colorectal cancer group, and 50 healthy persons who received enteroscopy examination (with intestinal discomfort and other related symptoms) as the control group. The expression of PTEN,COX2 protein was detected by immunohistochemical method in the four groups and the correlation between the expression of PTEN,COX2 protein and the prognosis of patients with recurrent and metastatic colorectal cancer was analyzed.【Results】 The positive rate of PTEN protein expression in patients with recurrence and metastasis was 20.00% (10/50), which was significantly lower than that in the other three groups, while that in the simple recurrence group was significantly lower than that in the primary colorectal cancer group and the control group. At the same time, the positive rate of COX2 protein expression in patients with recurrence and metastasis was 86.00% (43/50), which was significantly higher than that of the other three groups, and that of simple recurrence group was significantly higher than that of the primary colorectal cancer group and the control group. The difference was statistically significant (mean P<0.05). The positive rate of PTEN protein expression in the primary colorectal cancer group was lower than that in the control group, but the positive rate of COX2 protein expression was higher than that in the control group (mean P<0.05). The positive rate of PTEN protein expression in the survival patients was 32.14% (9/28), which was significantly higher than that in the dead patients (4.55%) (1/22). The positive rate of COX2 protein expression was 75.00% (21/28). It was significantly lower than that in the death patients (100.00%, 22/22), and the difference was statistically significant (P<0.05). The correlation analysis showed that the survival rate of patients with recurrent and metastatic colorectal cancer was positively correlated with the expression level of PTEN protein (r=0. 673, P<0.05). There was a significant negative correlation between the expression of COX2 protein and the expression of COX2 protein (r=-0.652,P=0.000).【Conclusion】 The expression of PTEN,COX2 protein can be used for early diagnosis of recurrent and metastatic colorectal cancer and as a prognostic indicator.

Key words： Intestinal Neoplasms/PP Proteins

Received: 29 March 2018

PACS:

R735.34

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	YANG Yong
	ZHAO Zi-long
	ZHOU Guo-jiang

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YANG Yong,ZHAO Zi-long,ZHOU Guo-jiang. Expression and Clinical Significance of PTEN and COX2 Protein in Patients with Recurrent Metastatic Colorectal Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(12): 2311-2313.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2018.12.007 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2018/V35/I12/2311

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