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| Relationship Among Coagulation Function, D-dimer Level and Coronary Artery Lesions in Children with Kawasaki Disease |
| ZHOU Yu-jie, CHEN Jie, LE Yang-hua, et al |
| The Department of Laboratory,People's Hospital of Hunan Province,Changsha 410002 |
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Abstract 【Objective】To investigate the relationship among coagulation function, D-dimer level and coronary artery lesions in children with Kawasaki Disease.【Methods】A total of 194 cases with Kawasaki disease children who were diagnosed in the department of pediatrics in our hospital were collected in the study. According to the results of heart echocardiography for coronary artery lesions, patients were divided into the coronary artery lesions group (CAL, n=42) and the no-coronary artery lesions group (NCAL, n=152). At the same time 60 healthy volunteers were formed the control group. . Blood coagulation function was tested in all subjects, including thrombin time (TT), partial prothrombin activation time (APTT), fibrinogen (FIB) quantitative values, and D - dimer level. The laboratory results were statistically analyzed. 【Results】 APTT and TT in both CAL and NCAL groups of Kawasaki disease were shorter than in the control group, while FIB and D - dimer were higher than the control group. The difference was statistically significant (P<0.05). There was a significant difference in the TT and D-dimer levels between the CAL group and the NCAL group (P<0.05). Logistic regression analysis indicated that TT was an independent influencing factor of coronary artery lesions (P<0.05). For every one second increase in TT of Kawasaki disease, the risk of coronary artery lesions increased by 0.838 -fold . The ROC curve area (AUCROC) for TT to diagnose coronary artery lesions of was 0.608. 【Conclusion】 Children with Kawasaki disease are hypercoagulable in the acute stage. Coagulation function TT is an independent and sensitive factor to indicate CAL. At the same time, it can also be speculated that coronary artery lesions is associated with vascular inflammation activity.
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Received: 13 April 2018
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2018, Vol. 35 
