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| The Effect of Family Empowerment Model on Immune Function and Treatment Compliance in Patients Undergoing Hematopoietic Stem Cell Transplantation |
| YANG Juanjuan |
| Nanyang Central Hospital,Nanyang Henan 473009 |
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Abstract 【Objective】 To explore the effect of family empowerment model on immune function and treatment compliance in patients undergoing hematopoietic stem cell transplantation (HSCT). 【Methods】A total of 86 HSCT patients admitted to Nanyang Central Hospital from June 2022 to June 2025 were enrolled and divided into observation group and control group by random number table method, with 43 cases in each group. The control group received routine nursing during the peri-transplantation period of HSCT, while the observation group received family empowerment model intervention on the basis of routine nursing. The immune function indicators (CD4+, CD8+, CD4+/CD8+ ratio), treatment compliance, Connor-Davidson Resilience Scale (CD-RISC) scores, and Revised Piper Fatigue Scale (RPFS) scores for cancer-related fatigue were compared between the two groups before intervention and at 6 months after intervention. 【Results】At 6 months after intervention, CD8+ levels decreased while CD4+ levels and CD4+/CD8+ ratio increased in both groups compared with baseline; the observation group had lower CD8+ level and higher CD4+ level and CD4+/CD8+ ratio than the control group, with statistically significant differences (all P<0.05). The scores of medication adherence including taking medicine on time and persistent medication were elevated in both groups after intervention, and these scores were higher in the observation group (all P<0.05). The scores of tenacity, strength, optimism, family support and interpersonal assistance were higher after intervention in both groups, and the observation group achieved higher scores than the control group (all P<0.05). The scores of cognition-emotion, affection, behavior, severity and sensory dimension of fatigue were reduced in both groups after intervention, and the observation group showed lower scores than the control group (all P<0.05). 【Conclusion 】 Family empowerment model can improve immune function, enhance treatment compliance and psychological resilience, and relieve cancer-related fatigue in HSCT patients.
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Received: 15 October 2025
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2026, Vol. 43 
