血浆置换术联合丙种球蛋白短程强化疗法在重症自身免疫性脑炎中的应用效果

doi:10.3969/j.issn.1671-7171.2026.08.022

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Abstract 【Objective】 To explore the application effect of plasma exchange combined with short-term intensive immunoglobulin therapy in patients with severe autoimmune encephalitis (AE). 【Methods】 A total of 102 patients with severe AE treated in the 905th Hospital of PLA Navy were randomly divided into the control group and the observation group, with 51 cases in each group. Patients in the control group received short-term intensive immunoglobulin therapy, while those in the observation group were additionally treated with plasma exchange in addition to that in the control group. The time to symptom resolution, serum inflammatory factor levels, immune function indicators (CD3⁺, CD4⁺, CD8⁺) before and after treatment, and the incidence of adverse reactions were compared between the two groups. 【Results】 The time to resolution of various symptoms in the observation group was significantly shorter than that in the control group (all P<0.05). After treatment, the levels of serum inflammatory factors in the observation group were lower than those in the control group(all P<0.05), and the improvement of immune function indicators was superior to the control group (all P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Plasma exchange combined with short-term intensive immunoglobulin therapy can significantly shorten the time to symptom resolution, reduce serum inflammatory factor levels and improve immune function in patients with severe AE, while demonstrating a favorable safety profile.

Key words： Autoimmune Encephalitis Plasm Permute Gamma Globulin

Received: 23 October 2025

PACS:

R512.3

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	Articles by authors
	DONG Peng
	LIU Ye
	WU Minlu
	LIU Jieyi

Cite this article:

DONG Peng,LIU Ye,WU Minlu, et al. Application Effect of Plasma Exchange Combined with Short-Term Intensive Immunoglobulin Therapy in Severe Autoimmune Encephalitis[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(8): 1312-1314.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.08.022 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I8/1312

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