三维超声容积成像评估自体PRP对薄型子宫内膜患者子宫内膜厚度及子宫内膜容受性的影响

doi:10.3969/j.issn.1671-7171.2026.04.020

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Abstract 【Objective】 To investigate the effect of autologous platelet-rich plasma (PRP) on endometrial thickness (EMT) and endometrial receptivity in patients with thin endometrium by using three-dimensional ultrasound volumetric imaging. 【Methods】 From August 2023 to March 2025, 120 patients with thin endometrium (during the mid-luteal phase, EMT ≤ 7 mm) were selected. Autologous PRP was perfused into the uterine cavity at the late follicular phase, and three-dimensional ultrasound volumetric imaging was performed before 1 week and 48 hours after the treatment to evaluate the changes in EMT, endometrial volume (EV), vascularization index (VI), blood flow index (FI), and continuity of the endometrial-myometrium junction (JZ) before and after the treatment. The clinical pregnancy rate 4 weeks after the first embryo transfer was statistically analyzed, and the relationship between the improvement degree of three-dimensional ultrasound volumetric imaging parameters and the pregnancy outcome was analyzed. 【Results】 After autologous PRP treatment for patients with thin endometrium, EMT increased from (6.2 ± 0.5) mm to (7.8 ± 0.6) mm, EV increased from (2.1 ± 0.4) mL to (3.7 ± 0.5) mL, VI increased from (0.82 ± 0.21) to (1.53 ± 0.33), and the differences were statistically significant (P<0.05). The proportion of patients with JZ continuity interruption exceeding 50% of the circumference decreased from 56.7% to 24.2% (P<0.05). The clinical pregnancy rate after autologous PRP treatment for patients with thin endometrium was 42.5% (51/120). The clinical pregnancy rates of patients with a pre-to-post-treatment EMT difference ≥ 1.5 mm and those with a post-treatment VI ≥ 1.5 were higher than those of patients with an EMT difference < 1.5 mm and with a post-treatment VI < 1.5 (P<0.05). The difference in VI before and after treatment was positively correlated with the clinical pregnancy rate (r= 0.734, P<0.05). 【Conclusion】 Three-dimensional ultrasound volumetric imaging shows that autologous PRP treatment for patients with thin endometrium can effectively improve the EMT, endometrial blood flow status, and endometrial receptivity of patients, thereby increasing the clinical pregnancy rate. The improvement of VI may be an effective indicator for predicting the therapeutic effect of autologous PRP treatment.

Key words： Endometrium Ultrasonography Platelet-Rich Plasma

Received: 16 July 2025

PACS:

R711.75

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LI Lin. Influence of Autologous PRP on Endometrial Thickness and Endometrial Receptivity in Patients with Thin Endometrium Evaluated by Three-Dimensional Ultrasound Volume Imaging[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(4): 599-602.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.04.020 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I4/599

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